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Fate of the mammalian cardiac neural crest.
TLDR
A two-component genetic system based on Cre/lox recombination is employed to label indelibly the entire mouse neural crest population at the time of its formation, and to detect it at any time thereafter.
Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.
TLDR
Intercrossing of heterozygotes from 24 strains that express beta-galactosidase identified 9 strains in which homozygosity leads to an embryonic lethality, suggesting that a substantial proportion of mammalian genes identified by this approach are not essential for development.
Src family kinases are required for integrin but not PDGFR signal transduction
TLDR
It is demonstrated that SFK activity is essential during embryogenesis and suggested that defects observed in SYF triple mutant embryos may be linked to deficiencies in signaling by extracellular matrix‐coupled receptors.
Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis.
TLDR
It is demonstrated, for the first time, that CNC cells contribute to the formation of condensed dental mesenchyme, dental papilla, odontoblasts, dentine matrix, pulp, cementum, periodontal ligaments, chondrocytes in Meckel's cartilage, mandible, the articulating disc of temporomandibular joint and branchial arch nerve ganglia.
The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites.
TLDR
Results indicate that PDGFs may exert their functions during early embryogenesis by affecting cell survival and patterning in mice carrying a targeted null mutation.
Neuronal position in the developing brain is regulated by mouse disabled-1
TLDR
It is shown that targeted disruption of the mouse disabled1 ( mdab1 ) gene disturbs neuronal layering in the cerebral cortex, hippocampus and cerebellum.
Evolutionary Divergence of Platelet-Derived Growth Factor Alpha Receptor Signaling Mechanisms
ABSTRACT Receptor tyrosine kinases (RTKs) direct diverse cellular and developmental responses by stimulating a relatively small number of overlapping signaling pathways. Specificity may be determined
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