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Generalized lacZ expression with the ROSA26 Cre reporter strain
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Fate of the mammalian cardiac neural crest.
A subpopulation of neural crest termed the cardiac neural crest is required in avian embryos to initiate reorganization of the outflow tract of the developing cardiovascular system. In mammalianExpand
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Src family kinases are required for integrin but not PDGFR signal transduction
Src family kinases (SFKs) have been implicated as important regulators of ligand‐induced cellular responses including proliferation, survival, adhesion and migration. Analysis of SFK function hasExpand
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Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis.
Neural crest cells are multipotential stem cells that contribute extensively to vertebrate development and give rise to various cell and tissue types. Determination of the fate of mammalian neuralExpand
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Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.
A general strategy for selecting insertion mutations in mice has been devised. Constructs lacking a promoter and including a beta-galactosidase gene, or a reporter gene encoding a protein with bothExpand
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Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
To understand the normal, physiological role of the c-src proto-oncogene, a null mutation was introduced into the gene by homologous recombination in mouse embryonic stem cells. Two independentExpand
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Neuronal position in the developing brain is regulated by mouse disabled-1
During mammalian brain development, immature neurons migrate radially from the neuroectoderm to defined locations, giving rise to characteristic cell layers,. Here we show that targeted disruption ofExpand
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The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites.
Platelet-derived growth factors (PDGFs) have been implicated in the control of cell proliferation, survival and migration. Patch mutant mice harbor a deletion including the PDGF alpha receptor geneExpand
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Mena, a Relative of VASP and Drosophila Enabled, Is Implicated in the Control of Microfilament Dynamics
Drosophila Enabled is required for proper formation of axonal structures and is genetically implicated in signaling pathways mediated by Drosophila AbI. We have identified two murine proteins, MenaExpand
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Evolutionary Divergence of Platelet-Derived Growth Factor Alpha Receptor Signaling Mechanisms
ABSTRACT Receptor tyrosine kinases (RTKs) direct diverse cellular and developmental responses by stimulating a relatively small number of overlapping signaling pathways. Specificity may be determinedExpand
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