Isabelle Boutron43
Gabriel Baron22
43Isabelle Boutron
22Gabriel Baron
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  • Bernard Iung, Gabriel Baron, Eric G Butchart, François Delahaye, Christa Gohlke-Bärwolf, Olaf W Levang +6 others
  • 2003
AIMS To identify the characteristics, treatment, and outcomes of contemporary patients with valvular heart disease (VHD) in Europe, and to examine adherence to guidelines. METHODS AND RESULTS The Euro Heart Survey on VHD was conducted from April to July 2001 in 92 centres from 25 countries; it included prospectively 5001 adults with moderate to severe(More)
  • Bernard Iung, Agnès Cachier, Gabriel Baron, David Messika-Zeitoun, François Delahaye, Pilar Tornos +4 others
  • 2005
AIMS To analyse decision-making in elderly patients with severe, symptomatic aortic stenosis (AS). METHODS AND RESULTS In the Euro Heart Survey on valvular heart disease, 216 patients aged > or =75 had severe AS (valve area < or =0.6 cm(2)/m(2) body surface area or mean gradient > or =50 mmHg) and angina or New York Heart Association class III or IV.(More)
OBJECTIVE To develop a disease activity index for patients with primary Sjögren's syndrome (SS): the European League Against Rheumatism (EULAR) Sjögren's syndrome disease activity index (ESSDAI). METHODS Thirty-nine SS experts participated in an international collaboration, promoted by EULAR, to develop the ESSDAI. Experts identified 12 organ-specific(More)
OBJECTIVES To assess quality of reporting of sample size calculation, ascertain accuracy of calculations, and determine the relevance of assumptions made when calculating sample size in randomised controlled trials. DESIGN Review. DATA SOURCES We searched MEDLINE for all primary reports of two arm parallel group randomised controlled trials of(More)
BACKGROUND Blinding is a cornerstone of treatment evaluation. Blinding is more difficult to obtain in trials assessing nonpharmacological treatment and frequently relies on "creative" (nonstandard) methods. The purpose of this study was to systematically describe the strategies used to obtain blinding in a sample of randomized controlled trials of(More)
  • Amélie Yavchitz, Isabelle Boutron, Aida Bafeta, Ibrahim Marroun, Pierre Charles, Jean Mantz +1 other
  • 2012
BACKGROUND Previous studies indicate that in published reports, trial results can be distorted by the use of "spin" (specific reporting strategies, intentional or unintentional, emphasizing the beneficial effect of the experimental treatment). We aimed to (1) evaluate the presence of "spin" in press releases and associated media coverage; and (2) evaluate(More)
BACKGROUND The US Food and Drug Administration Amendments Act requires results from clinical trials of Food and Drug Administration-approved drugs to be posted at within 1 y after trial completion. We compared the timing and completeness of results of drug trials posted at and published in journals. METHODS AND(More)
OBJECTIVE To compare estimates of intervention effects between single centre and multicentre randomised controlled trials with continuous outcomes. DESIGN Meta-epidemiological study. DATA SOURCES 26 meta-analyses totalling 292 randomised controlled trials (177 single centre, 115 multicentre) with continuous outcomes published between January 2007 and(More)
OBJECTIVE To investigate the effect of the CONSORT for Abstracts guidelines, and different editorial policies used by five leading general medical journals to implement the guidelines, on the reporting quality of abstracts of randomised trials. DESIGN Interrupted time series analysis. SAMPLE We randomly selected up to 60 primary reports of randomised(More)