Philippe Pierrat

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Nuclear receptors (NRs) bound to response elements mediate the effects of cognate ligands on gene expression. Their ligand-dependent activation function, AF-2, presumably acts on the basal transcription machinery through intermediary proteins/mediators. We have isolated a mouse nuclear protein, TIF1, which enhances RXR and RAR AF-2 in yeast and interacts in(More)
The incorporation of chloro, fluoro, or methoxy substituents on the pyridine ring of pyridyltrimethylsilanes allowed us to perform efficient Hiyama cross-coupling with various (het)aryl halides. The reactions proceeded smoothly at room temperature leading to the corresponding functional bis(het)aryl in fair to excellent yields. The presence of pyridine(More)
Cationic carbon dots were fabricated by pyrolysis of citric acid and bPEI25k under microwave radiation. Various nanoparticles were produced in a 20-30% yield through straightforward modifications of the reaction parameters (stoichiometry of the reactants and energy supply regime). Particular attention was paid to the purification of the reaction products to(More)
Biolabile cationic lipids were developed for efficient intracellular delivery of DNA and siRNA. The compounds have been designed starting from the membrane lipid DOPC in a way they may loose their cationic charge when exposed to an acidic and/or enzymatic stimulus, such as those met during the journey of a lipoplex in biological media. They demonstrated(More)
2-Chloro-5-bromopyridine was immobilized on polystyrene via selective introduction of a traceless silicon linker at the C-4 position. A useful scaffold was thus obtained, as demonstrated by efficient and selective reactions with polar and transition organometallic reagents, opening a new access to pyridine-based libraries of synthons and chromophores.
Highly functionalized fullerenes can be efficiently constructed by various techniques. However, the challenge is to synthesize highly symmetrical fullerenes. Recently, a number of X-ray structures have been disclosed showing the high symmetry of substituted fullerenes. By reviewing the major types of multi functionalized fullerenes through selected examples(More)
Hexaazido and hexaiodo macrocyclic methanofullerenes undergo high-yielding sixfold click reactions or sixfold Heck, Sonogashira and Suzuki cross-coupling reactions, respectively, to yield all organic building blocks for higher molecular architectures.
The diverse addition patterns of fullerene adducts make them attractive molecules, generating widespread application. Firstly, in terms of the latter, mono-adducts are extensively used in opto-electronic devices, owing to the fullerene core s capacity to accept up to six electrons. A second important application involves the utilization of fullerene adducts(More)
One of the potential benefits of drug delivery systems in medicine is the creation of nanoparticle-based vectors that deliver a therapeutic cargo in sufficient quantity to a target site to enable a selective effect, width of the therapeutic window depending on the toxicity of the vector and the cargo. In this work, we intended to improve the siRNA delivery(More)