Brigitte Malgrange4
Laurent Nguyen3
Morgan Bodson3
Ingrid Breuskin3
4Brigitte Malgrange
3Laurent Nguyen
3Morgan Bodson
3Ingrid Breuskin
Learn More
  • Ingrid Breuskin, Morgan Bodson, Nicolas Thelen, Marc Thiry, Laurence Borgs, Laurent Nguyen +4 others
  • 2010
The cochleo-vestibular ganglion contains neural crest-derived glial cells and sensory neurons that are derived from the neurogenic otic placode. Little is known about the molecular mechanisms that regulate the tightly orchestrated development of this structure. Here, we report that Sox10, a high-mobility group DNA-binding domain transcription factor that is(More)
  • Ingrid Breuskin, Morgan Bodson, Nicolas Thelen, Marc Thiry, Laurence Borgs, Laurent Nguyen +2 others
  • 2009
Transcription factors of the SoxE family are critical players that underlie various embryological processes. However, little is known about their function during inner ear development. Here, we show that Sox10 is initially expressed throughout the otic vesicle epithelium and becomes later restricted to supporting cells as cell differentiation proceeds in(More)
  • Ingrid Breuskin, Morgan Bodson, Nicolas Thelen, Marc Thiry, Laurent Nguyen, Shibeshih Belachew +2 others
  • 2008
Deafness commonly results from a lesion of the sensory cells and/or of the neurons of the auditory part of the inner ear. There are currently no treatments designed to halt or reverse the progression of hearing loss. A key goal in developing therapy for sensorineural deafness is the identification of strategies to replace lost hair cells. In amphibians and(More)
In mammals, degeneration of peripheral auditory neurons constitutes one of the main causes of sensorineural hearing loss. Unfortunately, to date, pharmacological interventions aimed at counteracting this condition have not presented complete effectiveness in protecting the integrity of cochlear neural elements. In this context, the protein kinase C (PKC)(More)
Homeodomain containing proteins are a broad class of DNA binding proteins that are believed to primarily function as transcription factors. Electrostatics interactions have been demonstrated to be critical for the binding of the homeodomain to DNA. An examination of the electrostatic state of homeodomain residues involved in DNA phosphate binding has(More)
The POU4F3 transcription factor is expressed in the cochlear and vestibular hair cells of the inner ear and its targeted deletion results in a loss of inner ear hair cells. The DFNA15 truncation mutation has been demonstrated to result in a loss of transcriptional activity, but an increase in the stability of the protein. Molecular modelling is utilised to(More)
  • 1