Philippe Leproux

Learn More
The accumulation of lipids in non-adipose tissues is attracting increasing attention due to its correlation with obesity. In muscle tissue, ectopic deposition of specific lipids is further correlated with pathogenic development of insulin resistance and type 2 diabetes. Most intramyocellular lipids are organized into lipid droplets (LDs), which are(More)
We present an experimental and numerical study of supercontinuum generation extended in the visible part of the spectrum by using a selective optical coupling of the pump wave in the largely anomalous dispersion regime. The broadband frequency generation is induced by an initial four-wave mixing process that converts the pump wave at 1064 nm into 831 nm(More)
Despite growing demand for truly naïve imaging, label-free observation of cilium-related structure remains challenging, and validation of the pertinent molecules is correspondingly difficult. In this study, in retinas and cultured cells, we distinctively visualized Rootletin filaments in rootlets in the second harmonic generation (SHG) channel, integrated(More)
We describe the generation of powerful dispersive waves that are observed when pumping a dual concentric core microstructured fiber by means of a sub-nanosecond laser emitting at the wavelength of 1064 nm. The presence of three zeros in the dispersion curve, their spectral separation from the pump wavelength, and the complex dynamics of solitons originated(More)
The mechanism of surfactant-induced cell lysis has been studied with quantitative coherent anti-Stokes Raman scattering (CARS) microspectroscopy. The dynamics of surfactant molecules as well as intracellular biomolecules in living Chinese Hamster Lung (CHL) cells has been examined for a low surfactant concentration (0.01 w%). By using an isotope labeled(More)
We experimentally demonstrate the nonlinear generation of frequency-dissymmetric sidebands by injecting picosecond pump pulses inside the fundamental mode of a silica-core photonic crystal fiber in its normal dispersion regime. A systematic analysis highlights the fact that this phenomenon is based on the combination of the two major nonlinear effects(More)
Spectroscopic optical coherence tomography (spectroscopic OCT) is an echographic-like optical method for biomedical functional imaging. Current spectroscopic optical coherence tomography (OCT) methods rely on a posteriori numerical calculation. We present an alternative for optically accessing the spectroscopic information in OCT, that is, without(More)
  • 1