Philippe L. Salomé

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Accumulation of advanced glycation end products (AGEs) is enhanced by chronic hyperglycemia and oxidative stress and this process may contribute to the pathogenesis of vascular disease. Skin autofluorescence (AF), a measure of accumulation of AGEs in skin collagen, is associated with vascular disease in patients with diabetes.   Because central obesity(More)
BACKGROUND Airflow obstruction in smokers is often diagnosed relatively late. Earlier detection of airflow obstruction and smoking cessation may result in significant health gain. OBJECTIVE To determine the prevalence of previously undetected persistent airflow obstruction according to WHO/GOLD criteria in male smokers aged 40 to 65 years and its(More)
BACKGROUND People with central obesity have an increased risk for developing the metabolic syndrome, type 2 diabetes and cardiovascular disease. However, a substantial part of obese individuals have no other cardiovascular risk factors, besides their obesity. High sensitivity C-reactive protein (hs-CRP), a marker of systemic inflammation and a predictor of(More)
OBJECTIVES To determine the feasibility of population-based screening for metabolic syndrome (MetS) in primary care with self-measurement of waist circumference (WC) as first step, and the prevalence of MetS in a Dutch city. METHODS A survey of 14,000 people on the list of primary care physicians in the city of IJsselstein. All adults between 20 and 70(More)
OBJECTIVE There is a lack of data on the progression from a healthy obese phenotype toward an unhealthy obese phenotype and the development of metabolic syndrome (MetS). Our aim was to assess the development of MetS 3 years after screening in centrally obese individuals with a healthy obese phenotype and to evaluate the usefulness of repeated screening. (More)
Coughing is usually caused by an uncomplicated respiratory tract infection for which antibiotics are not useful. Noscapine and codein are not advised. When the risk of complications is increased (because of age or relevant comorbidity), the decision to prescribe an antibiotic is based on the clinical presentation and any necessary additional investigations.(More)
A number of important changes have been made in the second revision of the guideline 'Asthma in children' from the Dutch College of General Practitioners. In children under the age of 6 years, the symptoms stuffiness and recurrent cough are no longer considered part of the symptomatic diagnosis of asthma. Wheezing has become the key symptom of asthma. In(More)
BACKGROUND Chronic obstructive pulmonary disease (COPD) is a major health problem with an estimated prevalence of 10-15% among smokers. The incidence of moderate COPD, as defined by the Global Initiative for Chronic Obstructive Lung Disease (GOLD), is largely unknown. AIM To determine the cumulative incidence of moderate COPD (forced expiratory volume in(More)
BACKGROUND Early detection and appropriate treatment of metabolic syndrome (MetS) can modify cardiometabolic risk factors and prevent cardiovascular disease. Optimal screening outcomes require follow-up management of MetS. OBJECTIVE To investigate the natural course of events in the first year after positive screening for MetS in primary care with regard(More)
BACKGROUND Early detection and treatment of the metabolic syndrome may prevent diabetes and cardiovascular disease. Our aim was to assess remission of the metabolic syndrome and its determinants after a population based screening without predefined intervention in the Netherlands. METHODS In 2006 we detected 406 metabolic syndrome cases (The National(More)