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- Jeffrey H. Kordower, Marina E. Emborg, +17 authors P. Aebischer
- Science
- 2000
Lentiviral delivery of glial cell line-derived neurotrophic factor (lenti-GDNF) was tested for its trophic effects upon degenerating nigrostriatal neurons in nonhuman primate models of Parkinson's… (More)
- Gwenaëlle Douaud, Véronique Gaura, +8 authors Philippe Remy
- NeuroImage
- 2006
The striatum, a subcortical structure, is the principal target of the neurodegenerative process in Huntington's disease (HD). The measurement of striatal atrophy using the bicaudate ratio on CT… (More)
- Gwenaëlle Douaud, Timothy Edward John Behrens, +10 authors Philippe Remy
- NeuroImage
- 2009
Although Huntington's disease is largely considered to be a subcortical disease, there is no clear consensus on whether all deep grey matter loss is a direct downstream consequence of the massive… (More)
- Emmanuel Brouillet, Francisco A. Conde, M Flynt Beal, Philippe Hantraye
- Progress in neurobiology
- 1999
Huntington's disease (HD) is an inherited, autosomal dominant, neurodegenerative disorder characterized by involuntary choreiform movements, cognitive decline and a progressive neuronal degeneration… (More)
- MarÃa Borrell-Pagès, Josep M Canals, +13 authors Sandrine Humbert
- The Journal of clinical investigation
- 2006
There is no treatment for the neurodegenerative disorder Huntington disease (HD). Cystamine is a candidate drug; however, the mechanisms by which it operates remain unclear. We show here that… (More)
- E Brouillet, Michèle Guyot, +4 authors Philippe Hantraye
- Journal of neurochemistry
- 1998
Chronic inhibition of succinate dehydrogenase (SDH) by systemic injection of the selective inhibitor 3-nitropropionic acid (3NP) has been used as an animal model for Huntington's disease (HD).… (More)
- Stéphane Palfi, Liza Leventhal, +7 authors Jeffrey H. Kordower
- The Journal of neuroscience : the official…
- 2002
The primate striatum contains tyrosine hydroxylase (TH)-immunoreactive (ir) neurons, the numbers of which are augmented after dopamine depletion. Glial cell line-derived neurotrophic factor (GDNF)… (More)
- Alexandra Benchoua, Yaël Trioulier, +9 authors Emmanuel Brouillet
- Molecular biology of the cell
- 2006
Alterations of mitochondrial function may play a central role in neuronal death in Huntington's disease (HD). However, the molecular mechanisms underlying such functional deficits of mitochondria are… (More)
- P. G. Henry, Caroline Dautry, Philippe Hantraye, Gérard Bloch
- Magnetic resonance in medicine
- 2001
A new scheme is proposed to edit the 3.0 ppm GABA resonance without macromolecule (MM) contamination. Like previous difference spectroscopy approaches, the new scheme manipulates J-modulation of this… (More)
- Nicolas Bizat, J Hermel, +7 authors Emmanuel Brouillet
- The Journal of neuroscience : the official…
- 2003
Striatal cell death in Huntington's Disease (HD) may involve mitochondrial defects, NMDA-mediated excitotoxicity, and activation of death effector proteases such as caspases and calpain. However, the… (More)