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Combinatorial active‐site variants confer sustained clavulanate resistance in BlaC β‐lactamase from Mycobacterium tuberculosis
Bacterial resistance to β‐lactam antibiotics is a global issue threatening the success of infectious disease treatments worldwide. Mycobacterium tuberculosis has been particularly resilient toExpand
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Design of a peptidic inhibitor that targets the dimer interface of a prototypic galectin
Galectins are small soluble lectins that bind β-galactosides via their carbohydrate recognition domain (CRD). Their ability to dimerize is critical for the crosslinking of glycoprotein receptors andExpand
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Étude du potentiel synergique des mutations de résistance aux inhibiteurs de la β-lactamase blac de mycobacterium tuberculosis
La resistance bacterienne aux antibiotiques de type β-lactame est un probleme majeur menacant le succes des traitements contre les maladies infectieuses a travers le monde. Mycobacterium tuberculosisExpand
Design of peptidic inhibitors targeting the dimerization interface of galectins
Galectins are small soluble lectins that bind to galactosides via their carbohydrate recognition domain (CRD). They are involved in a variety of biological functions such as cell adhesion andExpand
Binding of a Soluble meso-Tetraarylporphyrin to Human Galectin-7 Induces Oligomerization and Modulates Its Pro-Apoptotic Activity.
The selective targeting of protein-protein interactions remains a significant determinant for the proper modulation and regulation of cell apoptosis. Prototypic galectins such as human galectin-7Expand