Philippe Desaulniers

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Tyrosine phosphorylation events play major roles in the initiation and regulation of several functional responses of human neutrophils stimulated by chemotactic factors such as the bacterially derived tripeptide formylmethionyl-leucyl-phenylalanine (fMet-Leu-Phe). However, the links between the G protein-coupled receptors, the activation of the tyrosine(More)
The inflammatory response in acute gouty arthritis is in large part a result of the interaction between neutrophils and monosodium urate (MSU) crystals. The tyrosine kinase Syk, which has been largely associated with the phagocytic response by Fc receptors and with spreading mediated by integrins, has been identified as one of the major proteins(More)
OBJECTIVE To determine the presence and characterize the activity of a soluble activation factor rapidly released by human neutrophils after stimulation with monosodium urate (MSU) crystals. METHODS Supernatants from human neutrophils stimulated by MSU crystals for 5 to 60 min were tested for their ability to stimulate a chemotactic response, induce a(More)
We apply the Markov Game formalism to develop a context-aware approach to valuing player actions, locations, and team performance in ice hockey. The Markov Game formalism uses machine learning and AI techniques to incorporate context and look-ahead. Dynamic programming is applied to learn value functions that quantify the impact of actions on goal scoring.(More)
Using new game events and location data, we introduce a player performance assessment system that supports drafting, trading, and coaching decisions in the NHL. Players who tend to play in similar locations are clustered together using machine learning techniques, which capture similarity in styles and roles. Clustering players avoids apples-to-oranges(More)
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