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  • Philippe Coulombe, Geneviève Rodier, Stéphane Pelletier, Johanne Pellerin, Sylvain Meloche
  • Biology, Medicine
  • Molecular and cellular biology
  • 2003 (First Published: 1 July 2003)
  • Mitogen-activated protein (MAP) kinases are stable enzymes that are mainly regulated by phosphorylation and subcellular targeting. Here we report that extracellular signal-regulated kinase 3 (ERK3),Continue Reading
  • Stéphane Pelletier, François Duhamel, Philippe Coulombe, Michel Robert Popoff, Sylvain Meloche
  • Biology, Medicine
  • Molecular and cellular biology
  • 2003 (First Published: 15 February 2003)
  • As do cytokine receptors and receptor tyrosine kinases, G protein-coupled receptors (GPCRs) signal to Janus kinases (Jaks) and signal transducers and activators of transcription (STATs). However, theContinue Reading
  • Geneviève Rodier, Philippe Coulombe, Pierre-Luc Tanguay, Christel Boutonnet, Sylvain Meloche
  • Biology, Medicine, Chemistry
  • The EMBO journal
  • 2008 (First Published: 20 February 2008)
  • The p27(Kip1) ubiquitin ligase receptor Skp2 is often overexpressed in human tumours and displays oncogenic properties. The activity of SCF(Skp2) is regulated by the APC(Cdh1), which targets Skp2 forContinue Reading
  • Paul Déléris, Justine Rousseau, Philippe Coulombe, Geneviève Rodier, Pierre-Luc Tanguay, Sylvain Meloche
  • Biology, Medicine
  • Journal of cellular physiology
  • 2008 (First Published: 1 December 2008)
  • Mitogen-activated protein (MAP) kinases are typical examples of protein kinases whose enzymatic activity is mainly controlled by activation loop phosphorylation. The classical MAP kinases ERK1/ERK2,Continue Reading
  • Philippe Coulombe, Geneviève Rodier, Eric Bonneil, Pierre Thibault, Sylvain Meloche
  • Biology, Medicine
  • Molecular and cellular biology
  • 2004 (First Published: 15 July 2004)
  • Extracellular signal-regulated kinase 3 (ERK3) is an unstable mitogen-activated protein kinase homologue that is constitutively degraded by the ubiquitin-proteasome pathway in proliferating cells.Continue Reading
  • Annie Bibeau-Poirier, Simon-Pierre Gravel, +7 authors Marc J. Servant
  • Biology, Medicine
  • Journal of immunology
  • 2006 (First Published: 15 October 2006)
  • Activation of the innate arm of the immune system following pathogen infection relies on the recruitment of latent transcription factors involved in the induction of a subset of genes responsible forContinue Reading