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High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes.

• Philippe Cloutier, Racha Al-Khoury, +7 authors Benoit Coulombe
• Methods
• 2009

Thirty years of research on gene transcription has uncovered a myriad of factors that regulate, directly or indirectly, the activity of RNA polymerase II (RNAPII) during mRNA synthesis. Yet many… (More)

The Protein Interaction Network of the Human Transcription Machinery Reveals a Role for the Conserved GTPase RPAP4/GPN1 and Microtubule Assembly in Nuclear Import and Biogenesis of RNA Polymerase II*

• Diane Forget, A Lacombe, +7 authors Benoit Coulombe
• Molecular & cellular proteomics : MCP
• 2010

RNA polymerase II (RNAPII), the 12-subunit enzyme that synthesizes all mRNAs and several non-coding RNAs in eukaryotes, plays a central role in cell function. Although multiple proteins are known to… (More)

A Newly Uncovered Group of Distantly Related Lysine Methyltransferases Preferentially Interact with Molecular Chaperones to Regulate Their Activity

• Philippe Cloutier, Mathieu Lavallée-Adam, Denis Faubert, Mathieu Blanchette, Benoit Coulombe
• PLoS genetics
• 2013

Methylation is a post-translational modification that can affect numerous features of proteins, notably cellular localization, turnover, activity, and molecular interactions. Recent genome-wide… (More)

hnRNP proteins and splicing control.

• Rebeca Martínez-Contreras, Philippe Cloutier, Lulzim Shkreta, Jean-François Fisette, Timothée Revil, Benoit Chabot
• Advances in experimental medicine and biology
• 2007

Proteins of the heterogeneous nuclear ribonucleoparticles (hnRNP) family form a structurally diverse group of RNA binding proteins implicated in various functions in metazoans. Here we discuss recent… (More)

R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein

• Philippe Cloutier, Christian Poitras, +6 authors Benoit Coulombe
• Nature communications
• 2017

The R2TP/Prefoldin-like (R2TP/PFDL) complex has emerged as a cochaperone complex involved in the assembly of a number of critical protein complexes including snoRNPs, nuclear RNA polymerases and… (More)

Transcription Factor IIS Cooperates with the E3 Ligase UBR5 to Ubiquitinate the CDK9 Subunit of the Positive Transcription Elongation Factor B*

• Marilena Cojocaru, Annie Bouchard, +4 authors Benoit Coulombe
• The Journal of biological chemistry
• 2011

Elongation of transcription by mammalian RNA polymerase II (RNAPII) is regulated by specific factors, including transcription factor IIS (TFIIS) and positive transcription elongation factor b… (More)

Protein kinase C-dependent control of Bcl-x alternative splicing.

• Timothée Revil, Johanne Toutant, Lulzim Shkreta, Daniel Garneau, Philippe Cloutier, Benoit Chabot
• Molecular and cellular biology
• 2007

The alternative splicing of Bcl-x generates the proapoptotic Bcl-x(S) protein and the antiapoptotic isoform Bcl-x(L). Bcl-x splicing is coupled to signal transduction, since ceramide, hormones, and… (More)

Nuclear import of RNA polymerase II is coupled with nucleocytoplasmic shuttling of the RNA polymerase II-associated protein 2

• Diane Forget, A Lacombe, Philippe Cloutier, Mathieu Lavallée-Adam, Mathieu Blanchette, Benoit Coulombe
• Nucleic acids research
• 2013

The RNA polymerase II (RNAP II)-associated protein (RPAP) 2 has been discovered through its association with various subunits of RNAP II in affinity purification coupled with mass spectrometry… (More)

Regulation of molecular chaperones through post-translational modifications: decrypting the chaperone code.

• Philippe Cloutier, Benoit Coulombe
• Biochimica et biophysica acta
• 2013

Molecular chaperones and their associated cofactors form a group of highly specialized proteins that orchestrate the folding and unfolding of other proteins and the assembly and disassembly of… (More)

New insights into the biogenesis of nuclear RNA polymerases?

• Philippe Cloutier, Benoit Coulombe
• Biochemistry and cell biology = Biochimie et…
• 2010

More than 30 years of research on nuclear RNA polymerases (RNAP I, II, and III) has uncovered numerous factors that regulate the activity of these enzymes during the transcription reaction. However,… (More)

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