Philippe Clezardin

Learn More
BACKGROUND Receptor activator of NFkB (RANK), its ligand (RANKL) and the decoy receptor of RANKL (osteoprotegerin, OPG) play a pivotal role in bone remodeling by regulating osteoclasts formation and activity. RANKL stimulates migration of RANK-expressing tumor cells in vitro, conversely inhibited by OPG. MATERIALS AND METHODS We examined mRNA expression(More)
The molecular mechanisms by which tumor cells induce osteolytic metastases are likely to Involve tumor cell adhesion to bone as well as the release of soluble mediators from tumor cells that stimulate osteoclast mediated bone resorption. Bisphosphonates (BPs) are powerful Inhibitors of the osteoclast activity and are, therefore, used In the treatment of(More)
  • 1