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  • P. G. Fournier, Sandrine Boissier, +4 authors Philippe Clézardin
  • Medicine
  • Cancer research
  • 2002 (First Publication: 15 November 2002)
  • Bisphosphonates (BPs) are used currently in the treatment of patients with bone metastases because these compounds inhibit bone resorption. We examined here the effects of BPs on inhibition ofContinue Reading
  • Olivier Peyruchaud, Bent Winding, Isabelle Pécheur, Claire Marie Serre, Pierre Delmas, Philippe Clézardin
  • Medicine
  • Journal of bone and mineral research : the…
  • 2001 (First Publication: 1 November 2001)
  • A very common metastatic site for human breast cancer is bone. The traditional bone metastasis model requires human MDA-MB-231 breast carcinoma cell inoculation into the left heart ventricle of nudeContinue Reading
  • Akeila Bellahcène, Richard Bachelier, Cédric Detry, Rosette Lidereau, Philippe Clézardin, Vincent Castronovo
  • Biology, Medicine
  • Breast Cancer Research and Treatment
  • 2006 (First Publication: 12 January 2007)
  • Metastatic breast cancer cells exhibit the selective ability to seed and grow in the skeleton. We and others have previously reported that human breast tumors which metastasize to the skeletonContinue Reading
  • Maylis Raphaël, V'yacheslav Lehen'kyi, +12 authors Natalia Prevarskaya
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 2014 (First Publication: 29 August 2014)
  • Significance Transient receptor potential vanilloid subfamily member 6 (TRPV6) is a highly selective Ca2+ channel that exercises its normal physiological function via Ca2+ absorption in the intestineContinue Reading
  • Florence Daubiné, Céline Le Gall, Juerg Gasser, Jonathan Green, Philippe Clézardin
  • Medicine
  • Journal of the National Cancer Institute
  • 2007 (First Publication: 21 February 2007)
  • BACKGROUND Bisphosphonates exhibit direct antitumor activity in animal models, but only at high doses that are incompatible with the clinical dosing regimens approved for the treatment of cancerContinue Reading