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  • Philippe Bouillet, Donald Metcalf, +5 authors Andreas Strasser
  • Biology, Medicine
  • Science
  • 1999 (First Publication: 26 November 1999)
  • Apoptosis can be triggered by members of the Bcl-2 protein family, such as Bim, that share only the BH3 domain with this family. Gene targeting in mice revealed important physiological roles for Bim.Continue Reading
  • Junya Kuroda, Hamsa Puthalakath, +9 authors Andreas Strasser
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 2006 (First Publication: 3 October 2006)
  • Cell killing is a critical pharmacological activity of imatinib to eradicate Bcr/Abl+ leukemias. We found that imatinib kills Bcr/Abl+ leukemic cells by triggering the Bcl-2-regulated apoptoticContinue Reading