Philippe Bergeron

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In 1977 Frank Crow introduced a new class of algorithm for the generation of shadows. His technique, based on the concept of shadow volumes, assumes a polygonal database and a constrained environment. For example, polyhedrons must be closed, and polygons must be planar. This article presents a new version of Crow's algorithm, developed at the Universite de(More)
Structure- and property-based drug design is an integral part of modern drug discovery, enabling the design of compounds aimed at improving potency and selectivity. However, building molecules using desktop modeling tools can easily lead to poor designs that appear to form many favorable interactions with the protein's active site. Although a proposed(More)
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