Learn More
1 Preamble T hese recommendations are primarily intended to standardize health monitoring programmes and reporting. In this way they may also help to standardize the micro-biological quality of animals. However, it is not a requirement of these recommendations that animals tested are free from all of the microorganisms listed. Health monitoring is a complex(More)
Veterinary professionals working in partnership with other competent persons are essential for a successful animal care and use programme. A veterinarian's primary responsibilities are defined by their own professional regulatory bodies, but in this area of work there are further opportunities for contribution, which will assist in safeguarding the health(More)
To assess laser modulation of wound healing, full-thickness cutaneous wounds were produced in the backs of pigs, and subjected to treatment with helium-neon laser. For comparison, some wounds were treated with non-laser energy source (a tungsten light) or left untreated as controls. Type I and type III procollagen mRNA levels were determined in the wounds(More)
The purpose of the study reported here was to determine conditions for electrocardiographic monitoring in the Göttingen minipig in view of its use as a second non-rodent species in toxicology studies. Electrocardiograms were recorded from conscious minipigs (6/sex) maintained in a sling. The three standard bipolar limb leads (I, II, III), the three(More)
Practical implementation of the 3Rs at national and regional levels around the world requires long-term commitment, backing, and coordinated efforts by international associations for laboratory animal medicine and science, including the International Association of Colleges of Laboratory Animal Medicine (IACLAM) and the International Council for Laboratory(More)
Development of effective and safe treatments for companion animals with cancer requires the collaboration of numerous animal health professionals and the full engagement of animal owners. Establishing 'Best Practice Recommendations' for clinical trials in veterinary oncology represents an important step toward meeting the goal of rigorous clinical trial(More)
Haematological and clinical effects were evaluated after multiple blood samplings over 24 h in the laboratory rat and for up to 22 days after collection to determine the time required for a return to baseline values. Male and female Sprague-Dawley rats (n = 7/sex/group) were bled 4 times over 24 h and blood samples of 1.2, 1.6, 2.4 and 3.2 ml were taken.(More)
  • 1