Philippe Acar

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  • P Bonhoeffer, Y Boudjemline, Z Saliba, J Merckx, Y Aggoun, D Bonnet +4 others
  • 2000
BACKGROUND Valved conduits from the right ventricle to the pulmonary artery are frequently used in paediatric cardiac surgery. However, stenosis and insufficiency of the conduit usually occur in the follow-up and lead to reoperations. Conduit stenting can delay surgical replacement, but it aggravates pulmonary insufficiency. We developed an innovative(More)
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT * Exposure to bosentan was lower in paediatric pulmonary arterial hypertension (PAH) patients treated with the marketed adult formulation at a dose of about 2 mg kg(-1) when compared with adult PAH patients. * In healthy adult subjects, bosentan pharmacokinetics are less than dose-proportional at doses of >or=500 mg.(More)
INTRODUCTION A 14-year-old girl, followed in our department for Marfan syndrome, presented with postural headache for a month. Neurological examination was normal. The diagnosis of intracranial hypotension syndrome was suspected. DISCUSSION Bilateral subdural hematomas were found on brain magnetic resonance imaging (MRI), and spinal MRI showed large(More)
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