Philipp Holzer

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EphB4 and its cognitive ligand ephrinB2 play an important role in embryonic vessel development and vascular remodeling. In addition, several reports suggest that this receptor ligand pair is also involved in pathologic vessel formation in adults including tumor angiogenesis. Eph/ephrin signaling is a complex phenomena characterized by receptor forward(More)
Collections of electronic music are mostly organized according to playlists based on artist names and song titles. Music genres are inherently ambiguous and, to make matters worse, assigned manually by a diverse user community. People tend to organize music based on similarity to other music and based on the music's emotional qualities. Taking this into(More)
We propose a sketch-based system to design volume data from scratch. The user splits a surface model and paints brush strokes to volumetrically fill the 3D space. We extend exisiting sketch-based modeling systems in various ways. First, we use the cross-sectional plane as the interface to design internal structures. Second, the predefined surface geometries(More)
Careful use of the limited remaining fossil energy resources is important for both ecological and economical reasons. In addition to technical improvements, fuel consumption of a vehicle is influenced significantly by the driving behavior. Currently, only few in-car user interfaces are trying to promote a more fuel-efficient driving behavior. We propose(More)
Biomarkers for patient selection are essential for the successful and rapid development of emerging targeted anti-cancer therapeutics. In this study, we report the discovery of a novel patient selection strategy for the p53-HDM2 inhibitor NVP-CGM097, currently under evaluation in clinical trials. By intersecting high-throughput cell line sensitivity data(More)
Variants shown by the orientation of the cover-plate and of the superior articular facets of the sacrum have a considerable influence on the lumbosacral biostatistics. This can be illustrated by parallelograms of forces. If we assume a certain force stressing upon the sacrum, we are able to calculate the distribution of stress upon the cover-plate and the(More)
The orientation of the superior articular processes with regard to the upper end-plate of the sacrum does not depend on the inclination of the sacrum. This assertion can be made by interpreting certain angles already described in literature and may be confirmed by a research following strict biomechanic principles: The orientation of the articular processes(More)
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