Philipp Gruner

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We demonstrate the design and integration of droplet-based microfluidic devices with microoptical element arrays for enhanced detection of fluorescent signals. We show that the integration of microlenses and mirror surfaces in these devices results in an 8-fold increase in the fluorescence signal and in improved spatial resolution. Using an array of(More)
The present study was aimed at developing a new strategy to design and anchor custom-fitted implants, consisting of a head fixation device and a chronic recording chamber, on the skull of adult macaque monkeys. This was done without the use of dental resin or orthopedic cement, as these modes of fixation exert a detrimental effect on the bone. The implants(More)
Emulsions are metastable dispersions in which molecular transport is a major mechanism driving the system towards its state of minimal energy. Determining the underlying mechanisms of molecular transport between droplets is challenging due to the complexity of a typical emulsion system. Here we introduce the concept of 'minimal emulsions', which are(More)
BACKGROUND Animal models serve as an important tool to understand peri-implant infection. Most of the models use high bacterial loads (>10(4) colony forming units, CFU) to provide high infection rates. Therefore these animals evolve rather similarly, making comparison between groups and statistical analysis possible. On the other hand, to mimic clinical(More)
Ever since electroencephalographic research began, interest has been focused on problems of the physiology, pathology, and symptomatology of the relationship between sleep and wakefulness. Following preliminaries, the present paper describes a combined procedure for the determination of the EEG preferential frequency, and by random sampling statistically(More)
A method for the representation of EEG-parameters by means of a bidimensional plot of two signals is described. A block diagram is given for the recording of figures with phase-sensitive parameter variations, using an oscilloscope or an X-Y graphic recorder as a display. Charts for the determination of the setting parameters of a digital as well as an(More)
Mean frequency, % index and mean amplitudes in 3 frequency bands served as basis for a dynamic comparison of manual and computer assisted EEG analyses in healthy adults. In spite of inevitable methodical deviations it was possible to assume quite a good concordance for the significant data trends with but one exception. Among others the mean frequencies(More)
The results, gained in previous studies by means of computer-assisted interval analysis and amplitude analysis, of power spectra as well as of visuomanual pattern evaluation of the EEG during standardized mental load, were related to each other. Described are the significantly requirement-dependent trends of data in there three frequency bands. Under(More)
EEG signal from fronto-occipital derivation was recorded in 16 Ss during a mental performance test (modified "Konzentrations-Leistungs-Test" including four levels of performance). A balanced changer-over design was used. Interval histograms in four frequency bands (theta, alpha, beta-1 and beta-2 bands) were determined on the basis of peak detection. A(More)
EEG was recorded in 16 Ss. under conditions of a modified "Konzentrations-Leistung-Test" including four levels of performance (balanced change-over design), and histograms of the momentary values of the signal voltages (derivation F3/01) constructed for frequency bands 4...8 Hz, 8...13 Hz and 13...26 Hz. The type of performance affected significantly(More)