PhilipE. Leboit

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Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice

Michelle Aszterbaum, John Epstein, +4 authors Ervin H. Epstein
Nature Medicine
1999

Basal cell carcinomas, the commonest human skin cancers, consistently have abnormalities of the hedgehog signaling pathway and often have PTCH gene mutations. We report here that Ptch+/– mice develop… (More)

Nephrogenic fibrosing dermopathy.

Shawn Edwin Cowper, Lyndon D. Su, Jag Bhawan, Howard S Robin, PhilipE. Leboit
The American Journal of dermatopathology
2001

This report details the histopathologic findings in a unique fibrosing disorder that recently emerged among patients with renal disease. The affected patients were initially identified among… (More)

Classifying melanocytic tumors based on DNA copy number changes.

Boris C. Bastian, Adam B. Olshen, PhilipE. Leboit, Dan Pinkel
The American journal of pathology
2003

Melanoma and benign melanocytic nevi can overlap significantly in their histopathological presentation and misdiagnoses are common. To determine whether genetic criteria can be of diagnostic help we… (More)

Isolation of Rochalimaea species from cutaneous and osseous lesions of bacillary angiomatosis.

Jane E. Koehler, Frederick D. Quinn, Timothy G. Berger, PhilipE. Leboit, Jordan W. Tappero
The New England journal of medicine
1992

BACKGROUND Bacillary angiomatosis is characterized by vascular lesions, which occur usually in patients infected with the human immunodeficiency virus (HIV). A newly described gram-negative organism,… (More)

Histological Diagnosis of Nevi and Melanoma

histological diagnosis of nevi and melanoma rd.springer histological diagnosis of nevi and melanoma springer histological diagnosis of nevi and melanoma parcon histological diagnosis of nevi and… (More)

Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features.

Boris C. Bastian, PhilipE. Leboit, Daniel Pinkel
The American journal of pathology
2000

Spitz nevus is a benign melanocytic neoplasm that can be difficult or impossible to histologically distinguish from melanoma. We have recently described copy number increases of chromosome 11p in a… (More)

Molecular cytogenetic analysis of Spitz nevi shows clear differences to melanoma.

Boris C. Bastian, Ulrich Wesselmann, Dan Pinkel, PhilipE. Leboit
The Journal of investigative dermatology
1999

Spitz nevus is a benign neoplasm of melanocytes that can be difficult or impossible to distinguish from melanoma by clinical and histopathologic examination. We studied genomic DNA from 17 Spitz nevi… (More)

Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.

Nicholas J. Wang, Zachary Sanborn, +30 authors Raymond J. Cho
Proceedings of the National Academy of Sciences…
2011

Squamous cell carcinomas (SCCs) are one of the most frequent forms of human malignancy, but, other than TP53 mutations, few causative somatic aberrations have been identified. We identified NOTCH1 or… (More)

Gene amplifications characterize acral melanoma and permit the detection of occult tumor cells in the surrounding skin.

Boris C. Bastian, Mohamed Kashani-sabet, +5 authors Daniel Pinkel
Cancer research
2000

Acral melanoma (AM) is commonly distinguished from superficial spreading melanoma (SSM), the most common type of melanoma, by its clinical presentation as well as its ethnic distribution. However,… (More)

Scleromyxoedema-like cutaneous diseases in renal-dialysis patients

Shawn Edwin Cowper, Howard S Robin, Seth Steinberg, Lyndon D. Su, Sonal Gupta, PhilipE. Leboit
The Lancet
2000

15 renal dialysis patients have been identified with a skin condition characterised by thickening and hardening of the skin of the extremities and an increase in dermal fibroblast-like cells… (More)

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