Philip S Wells

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Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Clive Kearon, Elie A. Akl, +9 authors Susan R. Kahn
Chest
2012

BACKGROUND This article addresses the treatment of VTE disease. METHODS We generated strong (Grade 1) and weak (Grade 2) recommendations based on high-quality (Grade A), moderate-quality (Grade B),… (More)

Antithrombotic Therapy for VTE Disease: CHEST Guideline and Expert Panel Report.

Clive Kearon, Elie A. Akl, +12 authors Lisa K. Moores
Chest
2016

BACKGROUND We update recommendations on 12 topics that were in the 9th edition of these guidelines, and address 3 new topics. METHODS We generate strong (Grade 1) and weak (Grade 2) recommendations… (More)

Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis.

Philip S Wells, David R Anderson, +7 authors Michael J. Kovacs
The New England journal of medicine
2003

BACKGROUND Several diagnostic strategies using ultrasound imaging, measurement of D-dimer, and assessment of clinical probability of disease have proved safe in patients with suspected deep-vein… (More)

Oral rivaroxaban versus standard therapy for the treatment of symptomatic venous thromboembolism: a pooled analysis of the EINSTEIN-DVT and PE randomized studies

Martin H. Prins, Anthonie W. A. Lensing, +9 authors Philip S Wells
Thrombosis journal
2013

BACKGROUND Standard treatment for venous thromboembolism (VTE) consists of a heparin combined with vitamin K antagonists. Direct oral anticoagulants have been investigated for acute and extended… (More)

Systematic overview of warfarin and its drug and food interactions.

Anne Holbrook, Jennifer Pereira, +4 authors Philip S Wells
Archives of internal medicine
2005

BACKGROUND Warfarin is a highly efficacious oral anticoagulant, but its use is limited by a well-founded fear of bleeding. Drug and food interactions are frequently cited as causes of adverse events… (More)

Risk for heparin-induced thrombocytopenia with unfractionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis.

Nadine Martel, James M. Lee, Philip S Wells
Blood
2005

Heparin-induced thrombocytopenia (HIT) is an uncommon but potentially devastating complication of anticoagulation with unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH). Our… (More)

Comparison of low-intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolism.

Clive Kearon, Jeffrey S. Ginsberg, +17 authors Michael J. Gent
The New England journal of medicine
2003

BACKGROUND Warfarin is very effective in preventing recurrent venous thromboembolism but is also associated with a substantial risk of bleeding. After three months of conventional warfarin therapy, a… (More)

A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism.

Clive Kearon, Michael J. Gent, +9 authors Jim A. Julian
The New England journal of medicine
1999

BACKGROUND Patients who have a first episode of venous thromboembolism in the absence of known risk factors for thrombosis (idiopathic thrombosis) are often treated with anticoagulant therapy for… (More)

Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy.

Marc A Rodger, Susan R. Kahn, +11 authors Michael J. Kovacs
CMAJ : Canadian Medical Association journal…
2008

BACKGROUND Whether to continue oral anticoagulant therapy beyond 6 months after an "unprovoked" venous thromboembolism is controversial. We sought to determine clinical predictors to identify… (More)

Computed tomographic pulmonary angiography vs ventilation-perfusion lung scanning in patients with suspected pulmonary embolism: a randomized controlled trial.

David R Anderson, Susan R. Kahn, +15 authors Philip S Wells
JAMA
2007

CONTEXT Ventilation-perfusion (V(dot)Q(dot) lung scanning and computed tomographic pulmonary angiography (CTPA) are widely used imaging procedures for the evaluation of patients with suspected… (More)

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