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We have used aspiration and electrolytic lesions to investigate the contributions of cerebellar cortex to the acquisition and expression of conditioned eyelid responses. We show that lesions of the anterior lobe of rabbit cerebellar cortex disrupt the timing of previously learned conditioned eyelid responses. These short-latency responses were used as an(More)
Although much is known about the induction of synaptic plasticity, the persistence of memories suggests the importance of understanding factors that maintain synaptic strength and prevent unwanted synaptic changes. Here we present evidence that recurrent inhibitory connections in the CA1 region of hippocampus may contribute to this task by modulating the(More)
make this task virtually impossible. Thus, smoking gun experiments will probably require new technologies such as in vivo imaging of (many) individual synapses or the ability to tag recently modified synapses with a marker. Until then, the best approaches will require a series Houston, Texas 77030 of indirect observations that together support involvement(More)
Proteinase inhibitor 9 (PI-9) is a human serpin present in the cytoplasm of cytotoxic lymphocytes and epithelial cells. It inhibits the cytotoxic lymphocyte granule proteinase granzyme B (graB) and is thought to protect cytotoxic lymphocytes and bystander cells from graB-mediated apoptosis. Following uptake into cells, graB promotes DNA degradation, rapidly(More)
unlikely that any lesion or mutation inherently achieves a desirable level of component specificity. As such, the goals are to minimize the collateral effects and to employ behavioral analyses that can effectively exclude alterna-Keck Center for the Neurobiology tives. Attempts to demonstrate component specificity of Learning and Memory via histological(More)
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