Philip M. Sherman

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BACKGROUND The brain-gut axis is a key regulator of normal intestinal physiology; for example, psychological stress is linked to altered gut barrier function, development of food allergies and changes in behaviour. Whether intestinal events, such as enteric bacterial infections and bacterial colonisation, exert a reciprocal effect on stress-associated(More)
A 1116 bp open reading frame (ORF), designated jlpA, encoding a novel species-specific lipoprotein of Campylobacter jejuni TGH9011, was identified from recombinant plasmid pHIP-O. The jlpA gene encodes a polypeptide (JlpA) of 372 amino acid residues with a molecular mass of 42.3 kDa. JlpA contains a typical signal peptide and lipoprotein processing site at(More)
Campylobacter jejuni is the most common bacterial cause of enterocolitis in humans, leading to diarrhoea and chronic extraintestinal diseases. Although probiotics are effective in preventing other enteric infections, beneficial microorganisms have not been extensively studied with C. jejuni. The aim of this study was to delineate the ability of selected(More)
OBJECTIVES:To develop an international consensus on the definition of gastroesophageal reflux disease (GERD) in the pediatric population.METHODS:Using the Delphi process, a set of statements was developed and voted on by an international panel of eight pediatric gastroenterologists. Statements were based on systematic literature searches using Medline,(More)
The use of probiotics is increasing in popularity for both the prevention and treatment of a variety of diseases. While a growing number of well-conducted, prospective, randomized, controlled, clinical trials are emerging and investigations of underlying mechanisms of action are being undertaken, questions remain with respect to the specific immune and(More)
Adherence of intestinal pathogens, including Escherichia coli O157:H7, to human intestinal epithelial cells is a key step in pathogenesis. Probiotic bacteria, including Lactobacillus helveticus R0052 inhibit the adhesion of E. coli O157:H7 to epithelial cells, a process which may be related to specific components of the bacterial surface. Surface-layer(More)
BACKGROUND We previously showed that neonatal maternal separation (MS) of rat pups causes immediate and long-term changes in intestinal physiology. AIM To examine if administration of probiotics affects MS-induced gut dysfunction. METHODS MS pups were separated from the dam for 3 h/day from days 4 to 19; non-separated (NS) pups served as controls. Twice(More)
Probiotics are derived from traditional fermented foods, from beneficial commensals or from the environment. They act through diverse mechanisms affecting the composition or function of the commensal microbiota and by altering host epithelial and immunological responses. Certain probiotic interventions have shown promise in selected clinical conditions(More)
Helicobacter pylori(H. pylori)는 만성 위염과 소화성 궤양 등의 원인균으로 잘 알려져 있으며 위암과 mucosa associated lymphoid tissue(MALT)와의 관련성도 체계적으로 밝혀져 있 다. 개발도상국에서 H. pylori는 어려서부터 감염되게 되는데 대 부분의 경우 10세 이전에 감염이 시작된다 1) . 한번 감염되면 수 십 년 지속되는 것이 보통이며 자연 박멸률은 극히 낮다 2) . 한국 인에서의 H. pylori 감염의 혈청학적 역학 연구결과에서 보면, 5 세 미만에 1.1%, 5-10세 사이에 12.8%, 10-15세 사이에 20.4% 인 양성률이 20대에 들어서면 66.7%로 급격히(More)