Learn More
Several reports have demonstrated that cerebral blood flow decreases with age and may contribute to neurodegenerative changes found in aging animals and man. Because GH and insulin-like growth factor 1 (IGF-1) decrease with age and have an important role in vascular maintenance and remodeling, we hypothesized that the decrease in cerebral blood flow is(More)
The control of the local supply of oxygen to a skeletal muscle vascular bed was analyzed by: (1) determining if a relative oxygen lack causes vascular dilation, (2) ascertaining the vascular elements responsible for the dilation, and (3) attempting to elucidate the mechanism of the dilation. When the concentration of oxygen in the inspiratory air was(More)
OBJECTIVE The purpose of this manuscript is to review the literature concerning the alterations in the microvasculature in experimental hypertension and aging. We also present new unpublished data and results where previous studies have not addressed important questions. METHODS The new studies were performed using a chronic cranial window to allow(More)
One-hundred and seventy patients with 252 club feet treated by early posterior release were reviewed after a follow-up averaging 15 years 10 months. The feet were assessed both functionally and clinically and the results related to any bony deformity found radiographically; a satisfactory result was obtained in 81%. Lateral tibial torsion was examined and(More)
We studied the effects of three anesthetic agents on the central hemodynamics of spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats instrumented with chronic electromagnetic flow probes and arterial pressure catheters. Cardiovascular alterations due to ether, pentobarbital sodium (PBS; 50 mg/kg), and a 2% chloralose-7.5% urethan mixture (CU; 6(More)
The effect of three calcium entry blockers, nifedipine, nimodipine, and verapamil on the vascular density of the chick chorioallantoic membrane (CAM) was studied. Each compound was released onto the CAM for three days (Days 7-10 or Days 11-14 of incubation) from Elvax polymer sustained release pellets. Quantitation of the vascular density was obtained by(More)
Tibiofibular torsion was measured in normal and clubfoot populations. A gradual increase, up to skeletal maturity, was demonstrated in normal legs. Lateral tibiofibular torsion was reduced in patients at the completion of clubfoot treatment, and it was concluded that derotation braces did not influence this result.
The effect of adenosine on the vascular density of the chick chorioallantoic membrane was studied. Elvax polymer pellets containing 0.2-3.0 mg of adenosine were placed on the chorioallantoic membrane of 10-day embryos. Control pellets containing mannitol were placed at least 1 cm away. After 4 days the membrane was formalin-fixed and removed. A thin plastic(More)
The hemodynamic alterations associated with the developmental phase of high blood pressure were investigated in the spontaneously hypertensive rat (SHR). All hemodynamic measurements were made in unanesthetized, unrestrained SHR and Wistar-Kyoto (WKY) rats instrumented with chronic electromagnetic flow probes on the ascending aorta and arterial pressure(More)