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- Pavel Gris, Josee Gauthier, +8 authors Luda Diatchenko
- Molecular pain
- 2010

BACKGROUND
Opioids are the most widely used analgesics for the treatment of clinical pain. They produce their therapeutic effects by binding to mu-opioid receptors (MORs), which are 7 transmembrane domain (7TM) G-protein-coupled receptors (GPCRs), and inhibiting cellular activity. However, the analgesic efficacy of opioids is compromised by side-effects… (More)

- Maureen A Su, Dan Davini, +10 authors Mark S Anderson
- Journal of immunology
- 2012

Chronic inflammatory demyelinating polyneuropathy is a debilitating autoimmune disease characterized by peripheral nerve demyelination and dysfunction. How the autoimmune response is initiated, identity of provoking Ags, and pathogenic effector mechanisms are not well defined. The autoimmune regulator (Aire) plays a critical role in central tolerance by… (More)

- Francis Chi-Moon Lau, Philip K. W. Cheng, Savio S. H. Tse
- Comput. J.
- 2001

We study the p-median problem which is one the classical problems in location theory. For p = 2 and on a two-dimensional mesh, we give an O(mn 2 p)-time algorithm for solving the problem, where, assuming that m n, m is the number of rows of the mesh containing demand points, n the number of columns containing demand points, and p the number of demand points.

- Pavel Gris, Philip Cheng, John Pierson, William Maixner, Luda Diatchenko
- Methods in molecular biology
- 2010

Mu-opioid receptor (MOR) belongs to a family of heptahelical G-protein-coupled receptors (GPCRs). Studies in humans and rodents demonstrated that the OPRM1 gene coding for MOR undergoes extensive alternative splicing afforded by the genetic complexity of OPRM1. Evidence from rodent studies also demonstrates an important role of these alternatively spliced… (More)

- F C M Lau, P K W Cheng
- 2002

We study the p-median problem which is one the classical problems in location theory. For p = 2 a n d o n a t wo-dimensional mesh, we give a n O(mn 2 p)-time algorithm for solving the problem, where, assuming that m n, m is the numberofrows of the mesh containing demand points, n the number of columns containing demand points, and p the number of demand… (More)

We study the p-median problem which is one of the classical problems in location theory. For p = 2 and on a two-dimensional mesh, we give an O(mn 2 q)-time algorithm for solving the problem, where, assuming that m ≥ n, m is the number of rows of the mesh containing demand points, n the number of columns containing demand points and q the number of demand… (More)

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