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  • Steve M Taylor, Christian M Parobek, +23 authors Jonathan J. Juliano
  • Biology, Medicine
  • The Journal of infectious diseases
  • 2015 (First Publication: 1 March 2015)
  • Plasmodium falciparum parasites that are resistant to artemisinins have been detected in Southeast Asia. Resistance is associated with several polymorphisms in the parasite's K13-propeller gene. TheExpand
  • Sunil Parikh, J-B Ouedraogo, Joyce A. Goldstein, Philip J. Rosenthal, Deanna L. Kroetz
  • Medicine
  • Clinical pharmacology and therapeutics
  • 2007 (First Publication: 1 August 2007)
  • Metabolism of the antimalarial drug amodiaquine (AQ) into its primary metabolite, N-desethylamodiaquine, is mediated by CYP2C8. We studied the frequency of CYP2C8 variants in 275 malaria-infectedExpand
  • Bhaskar R Shenai, Puran Singh Sijwali, Abhishek Singh, Philip J. Rosenthal
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2000 (First Publication: 15 September 2000)
  • Trophozoites of the malaria parasitePlasmodium falciparum hydrolyze erythrocyte hemoglobin in an acidic food vacuole to provide amino acids for parasite protein synthesis. Cysteine proteaseExpand
  • Philip J. Rosenthal
  • Biology, Medicine
  • International journal for parasitology
  • 2004 (First Publication: 1 December 2004)
  • A number of cysteine proteases of malaria parasites have been described, and many more putative cysteine proteases are suggested by analysis of the Plasmodium falciparum genome sequence. Studies withExpand
  • Meera Venkatesan, Nahla B. Gadalla, +59 authors Carol Hopkins Sibley
  • Biology, Medicine
  • The American journal of tropical medicine and…
  • 2014 (First Publication: 1 October 2014)
  • Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquineExpand
  • Erica L Dahl, Jennifer L Shock, Bhaskar R Shenai, Jiri Gut, Joseph L. DeRisi, Philip J. Rosenthal
  • Medicine, Biology
  • Antimicrobial Agents and Chemotherapy
  • 2006 (First Publication: 1 September 2006)
  • ABSTRACT Tetracyclines are effective but slow-acting antimalarial drugs whose mechanism of action remains uncertain. To characterize the antimalarial mechanism of tetracyclines, we evaluated theirExpand