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OBJECTIVES This study assessed the prognostic value of peak cardiac power output, measured non-invasively during maximal cardiopulmonary exercise testing, against other exercise-derived haemodynamic variables in patients with chronic congestive heart failure. METHOD AND RESULTS Two hundred and nineteen unselected, consecutive patients with congestive(More)
OBJECTIVE To investigate whether physiological cardiac reserve can be measured in man without invasive procedures and whether it is a major determinant of exercise capacity. DESIGN Development of method of measurement and an observational study. SETTING A regional cardiothoracic centre. SUBJECTS 70 subjects with a wide range of cardiac function, from(More)
Despite major advances in the past two decades in drugs to improve the prognosis of patients with chronic heart failure (CHF), the quality of life of these patients is still quite poor. Patients with congestive heart failure are limited by exertional dyspnoea, which persists even after resolution of pulmonary oedema. The origin of the dyspnoea is complex.(More)
There is evidence that multiple benefits can be obtained through exercise training that leads to increases in peak oxygen consumption (V(O(2))). It is unclear whether significant improvements can also be achieved through unsupervised low-budget home-based training regimes, especially in terms of cardiac functional gains. A randomized cross-over trial was(More)
BACKGROUND Angiotensin converting enzyme inhibitors at high doses have been shown to improve prognosis of heart failure patients. Their beneficial effects on exercise capacity have been less convincing in large parallel group studies. The objective of this investigation was to explore the mechanisms involved in dose-related functional effects and to test(More)
The purpose of this study was to extend the findings of age-related changes in force fluctuation of musculature of the lower extremity by examining whether accuracy of movement differs between young, middle-aged, and older adults depending on the angular position of the lower leg when completing a continuous tracking task. Participants were 24 healthy young(More)
The purpose of this study was to establish if osteoarthritis in older adults was associated with ability to accurately and continuously track leg movement in a model of therapy to improve age-related impairments of proprioception, kinesthesia, and coordination of muscles at the knee joint. 24 older adults without osteoarthritis and 24 older adults with(More)