Philip Costello

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BACKGROUND In patients with acute pulmonary embolism (PE), rapid and accurate risk assessment is paramount in selecting the appropriate treatment strategy. Right ventricular (RV) enlargement on chest CT has previously been shown to correlate with an unstable hospital course, but its role as a predictor of death is unknown. METHODS AND RESULTS We evaluated(More)
BACKGROUND We investigated the prognostic role of right ventricular enlargement on multidetector-row chest CT in acute pulmonary embolism (PE). METHODS AND RESULTS We studied 63 patients with CT-confirmed PE who underwent echocardiography within the ensuing 24 hours. Adverse clinical events, defined as 30-day mortality or the need for cardiopulmonary(More)
OBJECTIVES The purpose of this study was to compare the prognostic role of various computed tomography (CT) signs of right ventricular (RV) dysfunction, including 3-dimensional ventricular volume measurements, to predict adverse outcomes in patients with acute pulmonary embolism (PE). BACKGROUND Three-dimensional ventricular volume measurements based on(More)
In daily clinical routine, computed tomography (CT) has practically become the first-line modality for imaging of pulmonary circulation in patients suspected of having pulmonary embolism (PE). However, limitations regarding accurate diagnosis of small peripheral emboli have so far prevented unanimous acceptance of CT as the reference standard for imaging of(More)
To evaluate the performance of dual-energy computed tomography (CT) for integrative imaging of the coronary artery morphology and the myocardial blood supply, 36 patients (15 women, mean age 57 +/- 11 years) with equivocal or incongruous single photon emission CT (SPECT) results were investigated by a single-contrast medium-enhanced, retrospectively(More)
Computed tomography (CT) is the modality of choice for evaluation of pancreatic disease. In this prospective study, images obtained with spiral CT, which enables examination of a region of the body in a single breath-hold, were compared with those obtained by means of dynamic CT with automatic table incrementation in two groups of 30 patients referred for(More)
Owing to ongoing technical refinements and intense scientific and clinical evaluations, computed tomography (CT) of the heart has left the research realm and matured into a clinical application that is about to fulfill its promise to replace invasive cardiac catheterization in selected patient populations. CT coronary angiography is technically more(More)
PURPOSE To prospectively evaluate the accuracy of 64-section computed tomographic (CT) coronary angiography for assessing significant stenosis on a global and segmental level, by using conventional coronary artery angiography as the reference standard. MATERIALS AND METHODS This study was HIPAA compliant and had local institutional review board approval.(More)
PURPOSE To retrospectively compare a split-bolus contrast medium injection protocol with a biphasic and a monophasic protocol in terms of visualization of the right and left heart, contrast medium-related streak artifacts, and level of attenuation in the cardiac chambers and coronary arteries at coronary computed tomographic (CT) angiography. MATERIALS(More)
Technical innovation is rapidly improving the clinical utility of cardiac computed tomography (CT) and will increasingly address current technical limitations, especially the association of this test with relatively high levels of radiation. Guidelines for appropriate indications are in place and are evolving, with an increasing evidence base to ensure the(More)