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A novel secreted glycoprotein that regulates bone resorption has been identified. The protein, termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily. In vivo, hepatic expression of OPG in transgenic mice results in a profound yet nonlethal osteopetrosis, coincident with a decrease in later stages of osteoclast differentiation.(More)
Society must respond to the growing demand for cognitive enhancement. That response must start by rejecting the idea that 'enhancement' is a dirty word, argue Henry Greely and colleagues. Today, on university campuses around the world, students are striking deals to buy and sell prescription drugs such as Adderall and Ritalin — not to get high, but to get(More)
T-cell activation requires co-stimulation through receptors such as CD28 and antigen-specific signalling through the T-cell antigen receptor. Here we describe a new murine costimulatory receptor-ligand pair. The receptor, which is related to CD28 and is the homologue of the human protein ICOS, is expressed on activated T cells and resting memory T cells.(More)
S82 Q&A Individual approach Jane Harding balances the pros and cons of New Zealand’s system and its focus on individual researchers Society benefits enormously from scientific research. We get new technologies, live longer and healthier lives, and gain deeper knowledge of our planet and the Universe. The issue of how to evaluate the fruits of research(More)
Mosaicism for two forms of ring 13 was found in a child with embryonal rhabdomyosarcoma of the bladder, minor anomalies, and developmental delay. Her chromosome constitution was 46,XX,r(13)(p11q34)/46,XX,r del(13)(p11q14). Both cell lines were present in lymphocytes and fibroblasts. The cell line with the smaller ring chromosome predominated in both(More)
Having a good mentor early in your career can mean the difference between success and failure in any field. look at what makes a good mentor. The Nature awards for creative mentoring in science were created on the premise that the mentorship of young researchers — although fully deserving of recognition — is perhaps the least remarked on of all the(More)
Although much work has been done by scientists in developing communications to non-scientist audiences, much less attention has been given by them to the ways in which those messages are interpreted. Here, I look at the published work that examines the issue. I focus on three contexts in particular: debates over the triple vaccine for measles, mumps and(More)
C O V ER IL LU ST R AT IO N ( P R EV IO U S P A G E) : C A R L D ET O R R ES CONTENTS 2001 WILL ALWAYS BE REMEMBERED AS THE YEAR OF THE HUMAN GENOME. The availability of its sequence transformed biology, and the exemplary way in which hundreds of researchers came together to form a public consortium paved the way for ‘big science’ in biology. It was an(More)
Prolyl oligopeptidases cleave peptides on the carboxy side of internal proline residues and their inhibition has potential in the treatment of human brain disorders. Using our docking program fitted, we have designed a series of constrained covalent inhibitors, built from a series of bicyclic scaffolds, to study the optimal shape required for these small(More)