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- Philip A. Marsden, Henry H Heng, +5 authors Keith T. Schappert
- The Journal of biological chemistry
- 1993
Endothelial nitric oxide (NO) synthase is a unique NO synthase isoform that is expressed constitutively by vascular endothelium both in vivo and in vitro and is believed essential to local vascular… (More)
- Stella Kourembanas, Philip A. Marsden, L P McQuillan, Douglas V Faller
- The Journal of clinical investigation
- 1991
Hypoxia in vivo is associated with constriction of the distal vasculature in the lung. Uniquely situated at the interface between blood and the vessel wall proper, the vascular endothelium may… (More)
- Jason E. Fish, C C Matouk, +4 authors Philip A. Marsden
- The Journal of biological chemistry
- 2005
Expression of endothelial nitric-oxide synthase (eNOS) mRNA is highly restricted to the endothelial cell layer of medium to large sized arterial blood vessels. Here we assessed the chromatin… (More)
- Yi Gang Wang, Olga Roche, +14 authors Michael Ohh
- Nature Medicine
- 2009
Tumor hypoxia is associated with disease progression, resistance to conventional cancer therapies and poor prognosis. Hypoxia, by largely unknown mechanisms, leads to deregulated accumulation of and… (More)
- Philip A. Marsden, Xiaoyang Wan, +14 authors Gary A. Levy
- The Journal of clinical investigation
- 2003
Fibrin deposition and thrombosis within the microvasculature is now appreciated to play a pivotal role in the hepatocellular injury observed in experimental and human viral hepatitis. Importantly,… (More)
VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail.
- Andrew J. Evans, Ryan C. Russell, +18 authors Michael Ohh
- Molecular and cellular biology
- 2007
The product of the von Hippel-Lindau gene (VHL) acts as the substrate-recognition component of an E3 ubiquitin ligase complex that ubiquitylates the catalytic alpha subunit of hypoxia-inducible… (More)
- Jean-Luc Balligand, Ralph A. Kelly, Philip A. Marsden, Th. W. Smith, Thomas Michel
- Proceedings of the National Academy of Sciences…
- 1993
Nitric oxide (NO) synthesized from L-arginine is a ubiquitous intracellular chemical messenger and is involved in signal transduction in diverse mammalian cells, including vascular endothelium and… (More)
- Yvonne Y Chan, Jason E. Fish, +7 authors Philip A. Marsden
- The Journal of biological chemistry
- 2004
The basis for the endothelial cell-restricted expression of endothelial nitric-oxide synthase (eNOS) is not known. While transgenic promoter/reporter mice demonstrated endothelium cell-specific eNOS… (More)
- Anne V Hall, H Antoniou, +6 authors Philip A. Marsden
- The Journal of biological chemistry
- 1994
Neuronal nitric oxide (NO) synthase, localized to human chromosome 12, uniquely participates in diverse biologic processes; neurotransmission, the regulation of body fluid homeostasis, neuroendocrine… (More)
- Yang Wang, Derek C Newton, Philip A. Marsden
- Critical reviews in neurobiology
- 1999
Neuronal nitric oxide synthase (nNOS) has been implicated in a wide variety of physiological and pathological processes. These include neurotransmission, neurotoxicity, skeletal muscle contraction,… (More)