Philip A. Mudd

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Developing a vaccine for human immunodeficiency virus (HIV) may be aided by a complete understanding of those rare cases in which some HIV-infected individuals control replication of the virus. Most of these elite controllers express the histocompatibility alleles HLA-B*57 or HLA-B*27 (ref. 3). These alleles remain by far the most robust associations with(More)
CD8+ T Lymphocytes (CTL) can control AIDS virus replication. However, natural selection favoring viral variants that escape CTL recognition is a common feature of both simian immunodeficiency virus (SIV) infection of macaques and HIV infection of humans. Emerging data indicate that CTL directed against alternate reading frame (ARF)-derived epitopes (a.k.a.(More)
INSA White Papers are printed on recycled paper that is 50% recycled content including 25% post consumer waste. The Task Force wishes to acknowledge the advice it received from a number of current and former intelligence and national security officials as well as members of INSA who enriched the paper through their contributions during Task Force meetings(More)
OBJECTIVE To investigate whether the location and extent of the CT hyperdense artery sign (HAS) at presentation affects response to IV alteplase in the randomized controlled Third International Stroke Trial (IST-3). METHODS All prerandomization and follow-up (24-48 hours) CT brain scans in IST-3 were assessed for HAS presence, location, and extent by(More)
Rats were taught to select eight holes in a 4 x 4 holeboard for food reinforcements. Upon reaching criterion, they were given subtotal lesions of the anterior hippocampus or sham operations. They then received either the calcium channel blocker, nimodipine, or vehicle alone. Retention testing revealed a significant main effect of lesion and evidence for(More)
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