Phil W. Pemberton

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BACKGROUND The burden of liver disease in the UK has risen dramatically and there is a need for improved diagnostics. AIMS To determine which breath volatiles are associated with the cirrhotic liver and hence diagnostically useful. METHODS A two-stage biomarker discovery procedure was used. Alveolar breath samples of 31 patients with cirrhosis and 30(More)
BACKGROUND Preclinical studies in endometrial cancer (EC) show that metformin reduces cellular proliferation by PI3K-AKT-mTOR inhibition. We tested the hypothesis that short-term presurgical metformin reduces cellular proliferation in atypical endometrial hyperplasia (AEH) and endometrioid EC, and assessed the feasibility of using phosphorylated(More)
BACKGROUND The aim of this study was to explore the influence of extended-release niacin/laropiprant (ERN/LRP) versus placebo on high-density lipoprotein (HDL) antioxidant function, cholesterol efflux, apolipoprotein B100 (apoB)-containing lipoproteins, and mediators of vascular inflammation associated with 15% increase in high-density lipoprotein(More)
OBJECTIVES The aim of the current study was to compare levels of vascular cell adhesion molecule-1 (VCAM-1) and E-selectin in lupus patients and controls and to investigate their association with clinical phenotype, disease activity and damage. METHODS We compared levels of serum VCAM-1 and E-selectin in 178 female lupus patients and 69 age-and(More)
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