BACKGROUND In school-aged children with cystic fibrosis (CF) structural lung damage assessed using chest CT is associated with abnormal ventilation distribution. The primary objective of this analysis was to determine the relationships between ventilation distribution outcomes and the presence and extent of structural damage as assessed by chest CT in… (More)
Early detection of liver metastases improves outcome in patients treated by chemotherapy, and is also associated with better survival in patients treated surgically. Large liver metastases (greater than about 1–2 cm in size) should be detectable by optimum quality CT or MRI techniques with a high level of accuracy. Microscopic metastases (smaller than 1–2… (More)
It has been shown that ultrasound and static isotope imaging are relatively insensitive for the detection of lesions <2cm diameter (Bryan et al., 1977). CAT scanning, although apparently more sensitive than these 2 methods still appears to have a limitation in detecting small lesions in the liver (Scherer et al., 1978). However, since it has been… (More)
It is important to distinguish liver metastases from incidental benign liver lesions which may be present in patients with cancer. In a minority of cases, sonography or CT may be sufficient to characterise benign lesions, but the range of sequences and contrast media available for liver MRI provides the opportunity for more specific diagnosis in the great… (More)
BACKGROUND Patients with Cystic Fibrosis (CF) are relatively insulinopenic and are at risk of diabetes, especially during times of stress. There is a paucity of data in the literature describing glucose tolerance during CF pulmonary exacerbations. We hypothesised that glucose tolerance would be worse during pulmonary exacerbations in children with CF than… (More)
43 non-surgical patients presenting with calf pain and a clinical diagnosis of deep venous thrombosis (DVT) were studied by arthrography, venography, and ultrasound. Only 14 had venographic evidence of DVT; 5 of these had popliteal cysts, which in 4 cases probably contributed to symptoms. 11 patients had popliteal cysts and normal venograms, and 9 of these… (More)
There is wide variability in the methods of follow up of patients with colorectal cancer. For the majority of patients follow up comprises regular clinical assessment and measurement of carcinoembryonic antigen (CEA) with interval colonoscopy. Regular CT examinations will additionally detect distant disease such as liver and pulmonary metastases as well as… (More)
Differences in QT dispersion (a predictor for sudden death) were observed in a subgroup of patients in the ELITE heart failure study of losartan compared with captopril, and may explain improved survival with losartan.