Phil M E Waite

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Recent reports have highlighted the potential therapeutic role of olfactory ensheathing cells for repair of spinal cord injuries. Previously ensheathing cells collected from the olfactory bulbs within the skull were used. In humans a source of these cells for autologous therapy lies in the nasal mucosa where they accompany the axons of the olfactory(More)
The outcome of spinal cord injury depends on the extent of secondary damage produced by a series of cellular and molecular events initiated by the primary trauma. This article reviews the evidence that secondary spinal cord injury involves the apoptotic as well as necrotic death of neurons and glial cells. Also discussed are the major factors that can(More)
We demonstrated recently that transplantation of olfactory ensheathing cells from the nasal olfactory mucosa can promote axonal regeneration after complete transection of the spinal cord in adult rat. Ten weeks after transection and transplantation there was significant recovery of locomotor behaviour and restoration of descending inhibition of spinal cord(More)
1. The region of the ventro-basal complex (VB) of the thalamus responding to movements of the whiskers has been mapped electrophysiologically in rats under either urethane or barbiturate anaesthesia.2. Whisker responses were found in the dorso-medial part of VB throughout its rostro-caudal extent; they occupied one third to one half of the total VB(More)
The infraorbital nerve was cut in either neonatal (on day 0) or adult (day 60) rats and the peripheral regeneration prevented. After 60 days either anatomical or electrophysiological techniques were used to study the peripheral nerve, trigeminal nucleus and somatosensory cortex. In neonatally sectioned animals the number of myelinated fibres surviving, at(More)
In patients with high spinal cord injuries autonomic dysfunction can be dangerous, leading to medical complications such as postural hypotension, autonomic dysreflexia and temperature disturbance. While animal models have been developed to study autonomic dysreflexia, associated temperature changes have not been documented. Our aim here was to use(More)
Hyperreflexia is a common feature of spinal cord injury (SCI), and changes in reflex excitability have been reported to be useful in assessing treatments in animal models of cord damage. However, spinal reflexes are known to be dependent on anesthetic level. As a preliminary to its use in SCI, the excitability of the Hoffman reflex (H reflex) has been(More)
The sequence of appearance of major forebrain projection and commissural fibre bundles in the tammar wallaby (Macropus eugenii) during development was examined with the aid of silver and haematoxylin stained material. At the time of birth (P0), the cerebral cortex is unformed, but two prominent fibre bundles are apparent in the forebrain: the medial(More)
This experiment examines the impact of the cholinergic input from the basal forebrain on the plasticity of the vibrissa-related somatosensory cortex. Newborn rat pups received intraventricular injections of the cholinergic immunotoxin IgG192-saporin, after bilateral removal of the C-line whisker follicles. Compared with saline-injected control animals,(More)
1. The responses of single cells to mechanical movements of individual whiskers have been recorded from the ventro-basal complex of the thalamus, in rats under urethane or barbiturate anaesthesia.2. With ramp-shaped displacements of a whisker above a critical velocity, the cells gave a short latency response of 1-5 impulses, while with sinusoidal movement(More)