Phil J. Howard

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We constructed maps for eight chromosomes (1, 6, 9, 10, 13, 20, X and (previously) 22), representing one-third of the genome, by building landmark maps, isolating bacterial clones and assembling contigs. By this approach, we could establish the long-range organization of the maps early in the project, and all contig extension, gap closure and(More)
Chromosome 9 is highly structurally polymorphic. It contains the largest autosomal block of heterochromatin, which is heteromorphic in 6-8% of humans, whereas pericentric inversions occur in more than 1% of the population. The finished euchromatic sequence of chromosome 9 comprises 109,044,351 base pairs and represents >99.6% of the region. Analysis of the(More)
We consider families of dynamics that can be described in terms of Perron-Frobenius operators with exponential mixing properties. For piecewise C 2 expanding interval maps we rigorously prove continuity properties of the drift J(λ) and of the diffusion coefficient D(λ) under parameter variation. Our main result is that D(λ) has a modulus of continuity of(More)
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