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OBJECTIVE To examine the safety of pertussis vaccination in pregnancy. DESIGN Observational cohort study. SETTING The UK Clinical Practice Research Datalink. PARTICIPANTS 20,074 pregnant women with a median age of 30 who received the pertussis vaccine and a matched historical unvaccinated control group. MAIN OUTCOME MEASURE Adverse events identified(More)
The monovalent H1N1 (2009) pandemic influenza vaccine used predominantly in the UK in 2009/10 was a split virion vaccine with a novel oil-in-water adjuvant (ASO3). While this was highly immunogenic it was also reactogenic especially for fever in children. There is a paucity of comparative data on reactogenicity of trivalent influenza vaccine (TIV). Using(More)
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