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Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an effort to identify regions with significant support for linkage in the combined data. The two primary analyses considered available linkage data for "very narrow"(More)
OBJECTIVES To identify the associations between two personality variables (alexithymia, negative affect), social support, awareness of myocardial infarction, and the severity of post-traumatic stress symptoms. DESIGN A cross sectional design was adopted with simultaneous measures of both dependent and independent variables. METHOD A random sample of 69(More)
CONTEXT Traditionally, the search for genes involved in predisposition to major psychoses has proceeded with separate studies of schizophrenia and bipolar disorder. However, twin data suggest that, in addition to genes with specificity for these phenotypes, there exist genes that simultaneously influence susceptibility to schizophrenia, bipolar disorder,(More)
CD8(+) cytotoxic T-lymphocytes (CTLs) perform a critical role in the immune control of viral infections, including those caused by human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). As a result, genetic variation at CTL epitopes is strongly influenced by host-specific selection for either escape from the immune response, or reversion(More)
Twenty-four subjects completed a study comparing the efficacy of a psychological treatment package suggested by Latimer (1983) and the best medical regime available in the treatment of the Irritable Bowel Syndrome (IBS). Initial anxiety levels were high in both groups and were reduced in the psychological, but not medical, condition. IBS symptoms and(More)
OBJECTIVE The purpose of this study was to identify correlates and predictors of the symptoms of post-traumatic stress disorder (PTSD) in a cohort of patients with myocardial infarction, while the patients were in hospital and 3 months after infarction. DESIGN Longitudinal, consecutive referrals were used. PATIENTS From a possible 68 consecutive(More)
BACKGROUND  Infection with hepatitis C virus (HCV) is a burgeoning worldwide public health problem, with 170 million infected individuals and an estimated 20 million deaths in the coming decades. While 6 main genotypes generally distinguish the global geographic diversity of HCV, a multitude of closely related subtypes within these genotypes are poorly(More)
UNLABELLED We investigated the migration patterns of hepatitis C virus (HCV) in China. Partial E1 and/or NS5B sequences from 411 volunteer blood donors sampled in 17 provinces and municipalities located in five large regions, the north-northeast, northwest, southwest, central south, and southeast, were characterized. The sequences were classified into eight(More)
The likelihood that milk and milk products may act as a vehicle for antibiotic-resistant bacterial genes has become a concern to the food industry and a public health issue, and the demand for rapid tests has increased. The purity of DNA extracted from food samples is a key issue in the sensitivity and usefulness of biological analyses, such as PCR for(More)
In a test of the predictive utility of the theory of planned behaviour alone and in conjunction with a number of additional variables, 114 participants completed questionnaires measuring predictor variables and, three weeks later, reported exercise. The results of the present study provide partial support for the theory. Past behaviour was the most(More)