Phelan Bybee

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Hepatocyte apoptosis or necrosis from accumulation of bile salts may play an important role in the disease progression of primary sclerosing cholangitis (PSC). The aim of the current study was to measure serum markers of hepatocyte apoptosis (cytokeratin-18 fragments—K18) and necrosis (high-mobility group protein B1—HMGB1) in adults with PSC and examine the(More)
BACKGROUND Ossabaw miniature swine when fed a diet high in fructose, saturated fat and cholesterol (NASH diet) develop metabolic syndrome and nonalcoholic steatohepatitis (NASH) characterized by liver injury and fibrosis. This study was conducted to further characterize the development of NASH in this large animal model. METHODS Ossabaw swine were fed(More)
Intradermal injection of compound 48/80 into the nuchal area of the guinea pig in an adjuvant/water emulsion induced strong delayed hypersensitivity. Groups of 8 animals were injected weekly for 3 weeks with 100 microliter of 10%, 1%, 0.1% or 0% of compound 48/80 in the adjuvant/water emulsion. 6 of 8 animals in the highest concentration group died between(More)
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