PhD O. E. Nieweg MD

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We provide a statistical analysis of the learning phase for sentinel node biopsy. Four learning phases were analyzed: 25, 50, 75, and 150 procedures with a corresponding number of 10, 20, 30, and 60 tumor-positive cases. Critical values of nonidentification rate and false-negative rate were defined. The binomial distribution was used to calculate the(More)
Older patients are assumed to have a higher risk of complications from isolated limb perfusion (ILP). A study was performed evaluating the safety and efficacy of ILP in patients older than 75 years with advanced melanoma of the limbs. A total of 218 therapeutic ILPs with melphalan with or without tumor necrosis factor α were performed in 202 patients with(More)
Background: The purpose of this study was to determine the feasibility of both lymphatic mapping and probe-guided primary tumor excision by use of intralesional tracer administration in clinically occult breast cancer. Methods: Sixty patients with a clinically occult breast lesion were prospectively included. Lymphoscintigraphy was performed after(More)
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