PhD J. W. Freston MD

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Experimental diet-induced dog gallstones contained mainly protein, mucous substances, bile salts, bilirubin, an insoluble pigment which formed an insoluble black residue after acid hydrolysis, and only traces of cholesterol. Added dietary cholesterol was necessary to pigmented gallstone production and led to hypercholesterolemia. In bile, the ratio of(More)
A unique columnar epithelium with elaborate microvilli, secretory granules, and the inability to absorb lipid lines the distal esophagus in many patients with midesophageal stricture. We studied this epithelium, obtained from 3 patients with midesophageal stricture and 1 with an esophageal (Barrett's) ulcer, by electron microscopy, enzyme histochemistry,(More)
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