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OBJECTIVES Chronic and high consumption of fat constitutes an environmental stress that leads to metabolic diseases. We hypothesized that high-fat diet (HFD) transgenerationally remodels the epigenome of spermatozoa and metabolism of the offspring. METHODS F0-male rats fed either HFD or chow diet for 12 weeks were mated with chow-fed dams to generate F1(More)
BACKGROUND Systemic kynurenine levels are associated with resistance to stress-induced depression and are modulated by exercise. Tryptophan is a precursor for serotonin and kynurenine synthesis. Kynurenine is transformed into the neuroprotective catabolite kynurenic acid by kynurenine aminotransferases (KATs). PGC-1α1 increases KAT mRNA and induces(More)
Recent decades have seen maternal obesity during pregnancy increase at an alarming rate. Maternal obesity or extreme weight gain during pregnancy leads to an adverse intrauterine environment that impacts embryonic programming and the offspring’s susceptibility to developing chronic metabolic diseases later in life. Regular exercise training is an effective(More)
OBJECTIVE Parental nutrition and lifestyle impact the metabolic phenotype of the offspring. We have reported that grandpaternal chronic high-fat diet (HFD) transgenerationally impairs glucose metabolism in subsequent generations. Here we determined whether grandpaternal diet transgenerationally impacts the transcriptome and lipidome in skeletal muscle. Our(More)
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