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OBJECTIVES Chronic and high consumption of fat constitutes an environmental stress that leads to metabolic diseases. We hypothesized that high-fat diet (HFD) transgenerationally remodels the epigenome of spermatozoa and metabolism of the offspring. METHODS F0-male rats fed either HFD or chow diet for 12 weeks were mated with chow-fed dams to generate F1(More)
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