Petros Christakis Papagiorgis

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The role of epidermal growth factor receptor (EGFR) in colorectal cancer (CRC) prognosis remains unclear despite the recent development of anti-EGFR treatments for metastatic disease. The heterogeneity of CRC may account for this discrepancy; proximal and distal CRC has been found to be genetically and clinicopathologically different. The aim of this study(More)
p53 and Bcl-2 (both regulators of cell apoptosis) have been considered to be involved in the initiation and progression of the colorectal tumorigenic process, respectively. In this study, we investigated their association with tumor stage and grade -both substantially affecting prognosis. Immunohistochemical assessment of p53 and Bcl-2 was retrospectively(More)
PURPOSE We investigated the biological behavior of proximal and distal colorectal adenocarcinomas (CRC), intending to determine specific segmental differences, possibly arising from the distinct genetic pathways involved in their development. METHODS Thirty-six proximal and 83 distal cancers were comparatively and retrospectively analyzed, regarding tumor(More)
Proximal and distal colorectal cancers (CRCs) are regarded as distinct disease entities, evolving through different genetic pathways and showing multiple clinicopathological and molecular differences. Segmental distribution of some common markers (e.g., KRAS, EGFR, Ki-67, Bcl-2, COX-2) is clinically important, potentially affecting their prognostic or(More)
A considerable change in the anatomical distribution of colorectal cancer (CRC) towards more proximal sites has been observed in Western countries within the last 6-7 decades. As a result, tumors located proximally to the splenic flexure are now accounting for 30-40% (or even more) of overall CRC cases. This proximal migration is not always representing a(More)
Colorectal cancer (CRC) is considered to develop through the conventional adenoma-carcinoma sequence. However, the existence of de novo carcinogenesis, without any intervening precursor lesions, has been suggested for certain morphologically different tumors lacking polypoid characteristics. The presence of such tumors, along with their correlation with(More)
PURPOSE Cancer of the colon and rectum has been classically viewed as the same disease entity. However, there are some differences both in the clinical features and gross macroscopic pathology between right and left sided colonic malignancies. Furthermore, recent research has added much controversy on the issue by demonstrating quite a few differences,(More)
PURPOSE Accumulated data seem to support the concept that proximal and distal colorectal cancers (CRC) should be considered as different disease entities. We investigated a particular aspect of this assumption by examining variation of stage and grade distribution according to tumor site in a Greek patients' group. METHODS A total of 200 cases having had(More)
Neurological diseases are not uncommon, exhibiting a lifetime prevalence of 6% in the general population being even higher among elderly. The trend of the most common neurological disorders (cerebrovascular disease, Parkinson, dementia, epilepsy) for presentation at older ages, the increasing need of elderly for surgery (of any type) and the demographic(More)
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