Petra M. G. Erkens

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IMPORTANCE D-dimer measurement is an important step in the diagnostic strategy of clinically suspected acute pulmonary embolism (PE), but its clinical usefulness is limited in elderly patients. OBJECTIVE To prospectively validate whether an age-adjusted D-dimer cutoff, defined as age × 10 in patients 50 years or older, is associated with an increased(More)
OBJECTIVE To validate the use of the Wells clinical decision rule combined with a point of care D-dimer test to safely exclude pulmonary embolism in primary care. DESIGN Prospective cohort study. SETTING Primary care across three different regions of the Netherlands (Amsterdam, Maastricht, and Utrecht). PARTICIPANTS 598 adults with suspected pulmonary(More)
INTRODUCTION The percentage of time within the target INR range 2.0 to 3.0 (TTR) in patients treated with vitamin K antagonists varies considerably among efficacy-studies of novel anticoagulants. In order to properly asses the quality of anticoagulant control in upcoming cost-effectiveness studies and real life registries this systematic review reports a(More)
OBJECTIVES The objective was to assess adverse outcomes in relation to the simplified Pulmonary Embolism Severity Index (PESI) score in patients treated with rivaroxaban or standard therapy in the phase III EINSTEIN PE study and to evaluate the utility of the simplified PESI score to identify low-risk pulmonary embolism (PE) patients. METHODS A post hoc(More)
OBJECTIVE To validate all diagnostic prediction models for ruling out pulmonary embolism that are easily applicable in primary care. DESIGN Systematic review followed by independent external validation study to assess transportability of retrieved models to primary care medicine. SETTING 300 general practices in the Netherlands. PARTICIPANTS(More)
INTRODUCTION Pulmonary embolism (PE) often presents with nonspecific symptoms and may be an easily missed diagnosis. When the differential diagnosis includes PE, an empirical list of frequently occurring alternative diagnoses could support the GP in diagnostic decision making. OBJECTIVES To identify common alternative diagnoses in patients in whom the GP(More)
1 , Petra M G Erkens clinical epidemiologist 2 , Wim A M Lucassen general practitioner 3 , Harry R Büller professor of medicine 4 , Hugo ten Cate professor of medicine 5 , Arno W Hoes professor of general practice 1 , Karel G M Moons professor of clinical epidemiology 1 , Martin H Prins professor of clinical epidemiology 2 , Ruud Oudega general practitioner(More)
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