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BACKGROUND Gray matter (GM) pathology has high clinical relevance in multiple sclerosis (MS), but conventional magnetic resonance imaging (MRI) is insufficiently sensitive to visualize the rather subtle damage. OBJECTIVE To investigate whether high spatial resolution T1-relaxation time (T1-RT) measurements can detect changes in the normal-appearing GM of(More)
This study aims to (1) investigate the neuropathology of mild to severe pediatric TBI and (2) elucidate the predictive value of conventional and innovative neuroimaging for functional outcome. Children aged 8–14 years with trauma control (TC) injury (n = 27) were compared to children with mild TBI and risk factors for complicated TBI (mildRF+, n = 20) or(More)
Highlights Intensity normalization has a large influence on white matter lesion • segmentation performance in patients with MS. Inclusion of tissue type priors as features increases the segmentation • performance of k nearest neighbor segmentation algorithms. Best segmentation performance was achieved by the configuration that • used variance scaling and(More)
Subtle gray matter damage was found in both thalamus and cortex of • patients with MS, as measured by increased skewness of the T1-relaxation time (RT) histogram compared to healthy controls. In the cortex, this increase was driven by the frontal and temporal lobes. No differences were found in other parameters. Increased skewness of the cortical T1-RT(More)
Background: Cortical lesions (CLs) occur frequently in multiple sclerosis (MS), but only few CLs are observed on conventional magnetic resonance imaging (MRI). Why some CLs are visible and others are not, is currently unknown. Here, we investigated whether CLs that are visible on conventional MRI differ from MRI-invisible CLs in terms of underlying(More)
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