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Die Einführung der neuen Sepsisdefinition im Frühjahr 2016 stellt ein neues Erklärungsmuster für das klinische Bild der Sepsis vor. Sepsis wurde bisher als systemische Entzündungsantwort („systemic inflammatory response syndrom“, SIRS) infolge einer Infektion definiert. Aufgrund eines besseren Verständnisses der molekularen Mechanismen ist der Fokus bei der(More)
Current risk assessment and risk communication of biosafety and biosecurity concerns lack a convenient metric and conceptual framework. The absence of such a systematic tool makes communication more difficult and can lead to ambiguous public perception of and response to laboratory biosafety incidents and biosecurity threats. A new 7-category scoring scale(More)
Working with highly pathogenic agents such as Ebola or Marburg virus in the context of infection control or biodefense research requires high-biocontainment laboratories of the Biosafety Level 4 (BSL-4) to protect researchers and laboratory staff from infection and to prevent the unintentional release of harmful agents. The public perception of research on(More)
A bioterrorist attack may result in a large number of people who have not been exposed coming to medical facilities in search of treatment or reassurance. In this article, we review evidence from 3 previous biological incidents that are analogous to a bioterrorist attack in order to gauge the likely incidence of such "low-risk patients" and to identify(More)
OBJECTIVE Risk communication plays a central role in the management of infectious disease. The World Health Organization's 2005 International Health Regulations have highlighted the need for countries to strengthen their capacities in this area to ensure effective responses to public health emergencies. We surveyed laboratories, hospitals, and public health(More)
BACKGROUND Health economics preference-based techniques, such as discrete choice experiments (DCEs), are often used to inform public health policy on patients' priorities when choosing health care. Although there is general evidence about patients' satisfaction with general-practice (GP) care in Europe, to our knowledge no comparisons are available that(More)
BACKGROUND Laboratory capacity building is characterized by a paradox between endemicity and resources: countries with high endemicity of pathogenic agents often have low and intermittent resources (water, electricity) and capacities (laboratories, trained staff, adequate regulations). Meanwhile, countries with low endemicity of pathogenic agents often have(More)
BACKGROUND The early detection of infectious disease outbreaks can reduce the ultimate size of the outbreak, with lower overall morbidity and mortality due to the disease. Numerous approaches to the earlier detection of outbreaks exist, and methods have been developed to measure progress on timeliness. Understanding why these surveillance approaches work(More)
ó Dass Wissen zur Bedrohung werden kann, ist keine neue Erkenntnis. Die Gefährlichkeit von Wissen, und auch wissenschaftlicher Erkenntnis, symbolisierte die Entwicklung der Atombombe, dramatisch umgesetzt in Dürrenmatts Die Physiker. Das 21. Jahrhun-dert rückt nun eine neue Forschergruppe in dieses zwiespältige Scheinwerferlicht: die Bio-logen, die(More)