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Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans
FOXP3+ regulatory T cells (Tregs) maintain tolerance against self-antigens and innocuous environmental antigens. However, it is still unknown whether Treg-mediated tolerance is antigen specific andExpand
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Flow‐cytometric analysis of rare antigen‐specific T cells
The cytometric enumeration and characterization of antigen‐specific lymphocytes, as introduced about 15 years ago, has contributed significantly to our understanding of adaptive immune responses inExpand
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Antigen-Reactive T Cell Enrichment for Direct, High-Resolution Analysis of the Human Naive and Memory Th Cell Repertoire
Ag-specific CD4+ T cells orchestrating adaptive immune responses are crucial for the development of protective immunity, but also mediate immunopathologies. To date, technical limitations oftenExpand
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Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans
Th17 cells provide protection at barrier tissues but may also contribute to immune pathology. The relevance and induction mechanisms of pathologic Th17 responses in humans are poorly understood.Expand
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Immune Responses to Broad-Spectrum Antibiotic Treatment and Fecal Microbiota Transplantation in Mice
Compelling evidence demonstrates the pivotal role of the commensal intestinal microbiota in host physiology and the detrimental effects of its perturbations following antibiotic treatment. Aim ofExpand
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The Probiotic Compound VSL#3 Modulates Mucosal, Peripheral, and Systemic Immunity Following Murine Broad-Spectrum Antibiotic Treatment
There is compelling evidence linking the commensal intestinal microbiota with host health and, in turn, antibiotic induced perturbations of microbiota composition with distinct pathologies. DespiteExpand
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New technologies for monitoring human antigen-specific T cells and regulatory T cells by flow-cytometry.
T cells orchestrate and execute immune responses against certain antigens recognized by their antigen receptor. They can acquire a highly divers set of functional properties, which provide the basisExpand
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CD137+CD154− Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures
Regulatory T cells (Tregs) are an attractive therapeutic tool for several different immune pathologies. Therapeutic Treg application often requires prolonged in vitro culture to generate sufficientExpand
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Fecal Microbiota Transplantation, Commensal Escherichia coli and Lactobacillus johnsonii Strains Differentially Restore Intestinal and Systemic Adaptive Immune Cell Populations Following
The essential role of the intestinal microbiota in the well-functioning of host immunity necessitates the investigation of species-specific impacts on this interplay. Aim of this study was to examineExpand
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The effect of regulatory T cells on tolerance to airborne allergens and allergen immunotherapy.
Forkhead box P3-positive regulatory T (Treg) cells are essential mediators of tolerance against self-antigens and harmless exogenous antigens. Treg cell deficiencies result in multiple autoimmune andExpand
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