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The neural pathways by which information about the acoustic world reaches the auditory cortex are well characterized, but how auditory representations are transformed into motor commands is not known. Here we use a perceptual decision-making task in rats to study this transformation. We demonstrate the role of corticostriatal projection neurons in auditory… (More)
Neural circuits are exquisitely organized, consisting of many different neuronal subpopulations. However, it is difficult to assess the functional roles of these subpopulations using conventional extracellular recording techniques because these techniques do not easily distinguish spikes from different neuronal populations. To overcome this limitation, we… (More)
The receptor tyrosine kinase product of the anaplastic lymphoma kinase (ALK) gene has been implicated in oncogenesis as a product of several chromosomal translocations, although its endogeneous role in the hematopoietic and neural systems has remained poorly understood. We describe that the generation of animals homozygous for a deletion of the ALK tyrosine… (More)
Perceptual decisions are based on the activity of sensory cortical neurons, but how organisms learn to transform this activity into appropriate actions remains unknown. Projections from the auditory cortex to the auditory striatum carry information that drives decisions in an auditory frequency discrimination task. To assess the role of these projections in… (More)
Brain regions contain diverse populations of neurons that project to different long-range targets. The study of these subpopulations in circuit function and behavior requires a toolkit to characterize and manipulate their activity in vivo. We have developed a novel set of reagents based on Pseudorabies Virus (PRV) for efficient and long-term genetic tagging… (More)
The neural pathways by which information about the acoustic world reaches the auditory cortex are well characterised, but how auditory representations are transformed into motor commands is not known. Here we have used a perceptual decision-making task to study this transformation. We directly demonstrate the role of corticostriatal projection neurones in… (More)
Parvalbumin interneurons in the cortex are believed to pool inputs from most surrounding excitatory cells independent of their functional properties. Response properties of interneurons in columnar visual cortex of ferrets, described by Wilson et al. (2017) in this issue of Neuron, challenge this view.
Acknowledgments We thank Barry Burbach for invaluable technical help.