Petr P. Purygin

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Changes in the peptide composition of hemolymph of Galleria mellonella larvae induced by their immunization have been studied, and some new peptides have been found. The composition of fractions exhibiting antibacterial activity was investigated. Known antibacterial peptides have been found in the hemolymph of control larvae and those immunized with(More)
Diazolides of carboxylic and thiocarboxylic acids have been used extensively in the synthesis of biologically active compounds [i, 2]. The use of N,N'-carbonyldiimidazole and N,N'-thiocarbonyldiimidazole has been particularly successful in the preparation of O-aminoacyl derivatives of nucleotides and nucleoside polyphosphates [3, 4]. In addition, it has(More)
The asymmetric unit of the title compound, C20H24N2O2S, contains two independent mol-ecules having very similar geometries. The main N-(6-meth-oxy-1,3-benzo-thia-zol-2-yl)acetamide moiety adopts an almost planar structure (r.m.s. deviations of 0.091 and 0.051 Å for the two independent molecules). The adamantyl substituent occupies the gauche position(More)
The antibacterial activity of hemolymph fractions isolated from Galleria mellonella larvae has been studied. Protein fractions possessing antibacterial activity were obtained using ion-exchange chromatography and gel electrophoresis techniques. MALDI-TOF mass-spectrometric analysis of these fractions showed the presence of a peptide with molecular mass 5627(More)
Biodegradation of alkyl-substituted adamantane derivatives (1-methyl, 1,3-dimethyl-, and 1,3,5-trimethyladamantane) by slow-growing bacteria Mycobacterium AGS10 was studied. The process was carried out under extremely acidic conditions (pH 2.5). Bacterial strain AGS10 was able to utilize these alicyclic hydrocarbons with a high degree of condensation and(More)
Many derivatives of imidazole and benzimidazole are widely used in industry, agriculture, photography, as well as in medical practice [1-4, 6, 9-11, 13]. Most of them have been studied for toxicity. The mutagenic activity of these compounds still has been little investigated. It was shown that benzimidazole does not show mutagenic activity on Drosophila(More)
Five-member nitrogen-containing heterocyeles enter into the composition of many important biogenic compounds (amino acids, alkaloids, purine bases) and serve as a base for many drug preparations [1]. As is known, imidazole derivatives suppress the activity of various microorganisms (by destroying their membrane systems), on the one hand, and are capable of(More)