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BACKGROUND This study examines the effect of initiating medications with anticholinergic activity on the cognitive functions of older persons. METHODS Participants were 896 older community-dwelling, Catholic clergy without baseline dementia. Medication data was collected annually. The Anticholinergic Cognitive Burden Scale was utilized to identify use of(More)
In diffuse large B-cell lymphoma (DLBCL), previous studies have suggested that, while concordant bone marrow (BM) involvement confers a poor prognosis, discordant BM involvement does not. Whether this correlation is independent of the non-Hodgkin lymphoma International Prognostic Index (IPI) was previously unknown. We reviewed all DLBCL case histories from(More)
Intrusion Prevention Systems (IPSs) not only attempt to detect attacks but also block malicious traffic and pro-actively tear down pertinent network connections. To effectively thwart attacks, IPSs have to operate both in real-time and inline fashion. This dual mode renders the design/implementation and more importantly the testing of IPSs a challenge. In(More)
Brain-derived neurotrophic factor (BDNF) plays a key role in energy balance. In population studies, SNPs of the BDNF locus have been linked to obesity, but the mechanism by which these variants cause weight gain is unknown. Here, we examined human hypothalamic BDNF expression in association with 44 BDNF SNPs. We observed that the minor C allele of(More)
We describe our approach to modeling timing of cell signaling systems in which existing information about the system spans from detailed mechanistic knowledge to much coarser observations about cause and effect. The results for several models emphasize the fact that the selection of timing implementation can have both qualitative and quantitative effects on(More)
Sessions generated by Instant Messaging and Peer-to-Peer systems (IM/P2Ps) not only consume considerable bandwidth and computing resources but also dramatically change the characteristics of data flows affecting both operation and performance of networks. Most IM/P2Ps have known security loopholes and vulnerabilities making them an ideal platform for(More)
The methylotrophic yeast Pichia pastoris has been used extensively for expressing recombinant proteins because it combines the ease of genetic manipulation, the ability to provide complex posttranslational modifications and the capacity for efficient protein secretion. The most successful and commonly used secretion signal leader in Pichia pastoris has been(More)
Vicinal proton-proton NMR couplings have been used to investigate whether the position of conformational equilibria is determined by intramolecular N-H hydrogen bonding for 2-(2'-pyridyl)ethylphosphonic acid 1 in its various possible ionization states in water, methanol, ethanol, and dimethyl sulfoxide (DMSO). With 1 in the form of its monoanion and(More)
The smart buildings today have various sensors to monitor its energy consumption, and will automatically adjust itself based on occupancy. However, current approaches are optimized for reducing energy consumption while preserving user experience. We believe that proactively modifying occupants' behavior is necessary to further reduce their energy footprint.(More)
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