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The interleukin-1 (IL-1) family of cytokines comprises 11 proteins (IL-1F1 to IL-1F11) encoded by 11 distinct genes in humans and mice. IL-1-type cytokines are major mediators of innate immune reactions, and blockade of the founding members IL-1alpha or IL-1beta by the interleukin-1 receptor antagonist (IL-1RA) has demonstrated a central role of IL-1 in a(More)
The innate immune system senses molecular patterns from invading microorganisms. Once activated, it orchestrates the inflammatory response by secreting proinflammatory cytokines, such as interleukin-1 (IL-1)-type cytokines, in particular IL-1beta. IL-1 mediates the expression of a vast array of genes involved in secondary inflammation. IL-1-responsive genes(More)
The interleukin-1 (IL-1) signalling pathway represents a paradigm for all IL-1 family cytokines (IL-1A, IL-1B, IL-18, IL-33, IL1F5 to IL1F10) as well as for the toll-like-receptor-induced pathways. Research on IL-1 signalling for more than 20 years has generated a large body of experimental data, which are scattered across many different publications. No(More)
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